Modern Approaches to an Initial and Anti-Relapse Treatment of Gastroesophageal Reflux Disease
Journal Title: Гастроентерологія - Year 2015, Vol 3, Issue 57
Abstract
The article deals with the modern approaches to an initial and anti-relapse treatment of gastroesophageal reflux disease (GERD), based on the recommendations of the last two American consensus. According to these data, the main drugs for the treatment of GERD are proton pump inhibitors (PPIs), which are divided into the first- and second-generation drugs and can be used in standard doses, as well as in double- and half-doses. Second-generation drugs are more effective and safe as they less dependent on CYP2C19 polymorphism of. It is concluded that in most cases, the initial treatment should begin with the use of standard or double-doses of PPI, and supporting one — with standard or half-doses used for a variety of schemes — constant, intermittent or therapy «on demand». The best preparation for a long-term treatment of GERD, especially if it is necessary to take other drugs, is pantoprazole.
Authors and Affiliations
S. M. Tkach
Keywords
Related Articles
- EP ID EP214482
- DOI -
- Views 68
- Downloads 0
The main approaches to the prevention of viral hepatitis A
Currently, the prevention of hepatitis A in populations with the intermediate level of endemicity is a significant issue. Vaccination associated with the importance of environmental and personal hygiene and sanitation ar...
Zemstvo Doctor and Dramatist
The study of the life and professional activity of Hryhorii Maksymovych Borakovskyi (1846–?), zemstvo doctor, doctor of medicine, forensic expert, public figure, writer, extraordinary personality, has been carried out. H...
Rotavirus-Induced Activation of the Defense Mechanisms of the Adaptive Immune System in Child’s Body
The review describes the current understanding on the participation of the adaptive immune system in sanogenesis at rotavirus infection. It is shown that the leading component of the nonspecific defense mechanisms of the...
Glycyrrizinic acid: pathophysiological aspects of fibrosis formation and effectiveness in treatment of liver diseases
The review article presents current data on the causes of the onset and development of liver fibrosis. This condition is due to excessive accumulation of the extracellular matrix, the producer of which is mainly hepatic...
Histometric Features of Endocrine Islets of the Pancreas in Chronic Pancreatitis
Long-existing chronic pancreatitis (CP) in the last stages of development leads to the destruction of the endocrine pancreatic tissue, but the mechanisms of these changes are not well understood. The aim of the study was...