CHANGING TRENDS IN BACTERIAL SPECTRUM OF NEONATAL SEPSIS AT A TERTIARY CARE TEACHING HOSPITAL - 2011 TO 2015
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 65
Abstract
BACKGROUND The organisms causing neonatal sepsis and their antimicrobial susceptibility patterns are highly diverse and vary geographically, temporally and locally attributed to changing pattern of antimicrobial use. Therefore, a continuous surveillance of sepsis is of utmost importance to ensure early diagnosis and appropriate therapy. This requires an understanding of changing trends in prevalent organisms and their antimicrobial susceptibility pattern. The aim of the present study was to determine the bacteriological profile and antimicrobial susceptibility pattern of organisms causing neonatal sepsis over a period of five years. METHODS This was a retrospective, hospital based single centre study. Microbiological data recorded from January 2011 to December 2015 was analysed. Blood cultures of all neonates with clinically suspected neonatal sepsis were included. Repeat isolation of the same species from the same neonate was excluded from analysis. Repeat blood cultures were advised when Coagulase-negative staphylococci (CoNS) were isolated. RESULTS Of a total of 10399 neonates included in the study, culture positivity was 12.1% over five years (Range – 10.4% to 15.7%). CoNS remained the most commonly isolated organism over the five-year study period (36.2%) with a high level of methicillin resistance. Enterobacteriaceae demonstrated high levels of resistance to all antibiotics tested. A similar rising trend in resistance for the years 2011 and 2014 was observed for non-fermenting Gram negative bacilli. A fall in percentage resistance to all antibiotics tested was observed in year 2015. CONCLUSIONS In spite of judicious antimicrobial use, a rising trend in antimicrobial resistance is observed. Improving infection control measures would perhaps help in controlling the spread of these resistant organisms.
Authors and Affiliations
Priyanka Prasad, Gita , Ruchi Nanavati, Preeti Mehta
Keywords
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- EP ID EP159729
- DOI 10.14260/jemds/2016/1055
- Views 81
- Downloads 0
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