Efficacy and safety of two doses of oral midazolam as premedication in paediatric patients: A prospective randomized and comparative study.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 6
Abstract
The present study was conducted to assess and compare the efficacy and safety of two doses of oral midazolam as premedication in pediatric patients undergoing surgeries under general anesthesia. Forty children aged 1-5 years were enrolled and randomly assigned to one of the two groups and received oral preparation of midazolam in two doses of 0.5 mg/kg and 0.75 mg/kg in two groups respectively, 30 minutes before separation from parents. They were assessed for patient’s acceptance of the medication , reaction to separation from parents, sedation scores and recovery conditions. With regard to children’s reaction to separation from their parents, the number of comfortable children was more in group B (18,90%) as compared to group A (15,75%). On arrival to the operation room eight children (40%) had satisfactory sedation scores in group B as compared to 5(25%) in group A. Satisfactory sedation score was also higher in group B (10,50%) as compared to group A (4,20%) after reversal of residual paralysis. Time to spontaneous ventilation and extubation and time from pre-medication to full recovery were not different in two groups. Oral midazolam in a dose of 0.75 mg/kg is an acceptable, effective and safe premedication in children aged 1-5 years.
Authors and Affiliations
Pooja Vaskle1 , Rashmi Pal2, KK Arora3
Keywords
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