EFFICACY OF RECOMBINANT EPIDERMAL GROWTH FACTOR IN THE HEALING PROCESS OF DIABETIC ULCER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 31
Abstract
OBJECTIVES To evaluate the efficacy of the Recombinant Epidermal Growth Factor in the healing of diabetic ulcer. To assess the tolerability of the Recombinant Epidermal Growth Factor in the diabetic ulcer management. METHODS Study Design: Randomized, interventional, prospective, comparative study. Study Centre: Department of General Surgery and Department of Diabetology, Thanjavur Medical College Hospital, Thanjavur. Study Period: February 2014-August 2015. Duration of Study: 18 Months. Sample Size: 60 (30+30), Study group A-30, Study group B-30. Sample Drug: Recombinant Epidermal Growth Factor. Selection Criteria. Inclusion Criteria 1. Age - 20-70 years. 2. Both sexes. 3. Fasting blood sugar <130 mgs/dL and postprandial blood sugar >130 mgs/dL <180 mgs/dL with treatment. 4. Patients with Grade 2 diabetic ulcer. 5. Patients with diabetes along with comorbidities like hypertension with BP <140/90 mmHg with antihypertensives, anaemia with haemoglobin between 8-10 gms%, chronic renal failure Stage 1 and 2, CAHD patients on drugs with no symptoms at present. 6. Palpable peripheral pulses or Doppler showing flow in peripheral vessels. 7. Patients who give consent and are willing for regular followup. Exclusion Criteria 1. Patients with extensive gangrenous changes. 2. Patients with vascular occlusion (Absent peripheral pulses or no flow in peripheral vessels in the Doppler study). 3. Patients with diabetic ketoacidosis or with fasting blood sugar >130 mgs/dL, postprandial blood sugar >180 mgs/dL in spite of treatment. 4. Patients with diabetes with hypertension with BP >140/90 mmHg, anaemia with haemoglobin <8 gms%, chronic renal failure with stage 3, 4, 5 congestive heart failure and recent onset myocardial infarction. 5. Pregnant or breastfeeding women. 6. Not willing for the study or not willing for regular visits. CONCLUSION The conclusion of this study is that Recombinant Epidermal Growth Factor is effective in the healing of diabetic ulcers at significantly higher rate. No adverse reactions are encountered. It is tolerated well by all the patients.
Authors and Affiliations
Antony , Rasool Raj
Keywords
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- EP ID EP144098
- DOI 10.14260/jemds/2016/387
- Views 80
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