The safety and efficacy of 3 percent Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 4
Abstract
Escalated sebum fabrication is seen with an unattractive look and adds to the growth of acne. We aimed to investigate the efficacy and safety of 3% Cannabis seeds extract cream on human cheek skin sebum and erythema content. For this purpose, base plus 3% Cannabis seeds extract and base (control) were prepared for single blinded and comparative study. Healthy males were instructed to apply the base plus 3% Cannabis seeds extract and base twice a day to their cheeks for 12 weeks. Adverse events were observed to determine skin irritation. Measurements for sebum and erythema content were recorded at baseline, 2nd, 4th, 6th, 8th, 10th and 12th week in a control room with Sebumeter and Mexameter. Base plus 3% Cannabis seeds extract was found to be safe in volunteers. Measurements demonstrated that skin sebum and erythema content of base plus 3% Cannabis seeds extract treated side showed significant decrease (p<0.05) compared with base treated side. Base plus 3% Cannabis seeds extract showed safety. It was well tolerated for the reduction of skin sebum and erythema content. Its improved efficacy could be suggested for treatment of acne vulgaris, seborrhea, papules and pustules to get attractive facial appearance.
Authors and Affiliations
Atif Ali , Naveed Akhtar
Keywords
Related Articles
- EP ID EP117043
- DOI -
- Views 71
- Downloads 0
Effect of some plants’ extracts used in Sudanese folkloric medicines on carrageenan-induced inflammation
Investigations for anti-inflammatory potential and categorization of Sudanese medicinal plants according to their potency. Anti-inflammatory effect of plants’ extracts of 17 genera were studied using the carrageena...
Research on green supply chain coordination strategy for uncertain market demand
Based on the status that the green market began to develop (e.g. pharmaceutical industry) in Mainland China, the paper mainly discusses how members of the green supply chain (GSC) cooperate effectively in the proce...
Biological Screening of Elaeagnus umbellata Thunb.
The bark and fruit extracts of Elaeagnus umbellata have been investigated for their antibacterial, anti-fungal, insecticidal and phytotoxic activities. The petroleum ether extracts of the plant showed significant a...
Study investigating the impact of pharmacist involvement on the outcomes of diabetes medication therapy adherence program Malaysia
Involvement of pharmacists in improving medication adherence among diabetic patients is recognized globally. In Malaysian healthcare system, pharmacists are also operating health services i.e. Diabetes Medication T...
Acoustical behavior of some amino acids in aqueous disodium citrate solutions over temperature range (298.15-313.15) K
Sound velocity, U, and density, ρ, of some amino acids viz. glycine, methionine, phenylalanine and tryptophan were determined in 0.1, 0.2 and 0.3 mol kg−1aqueous disodium citrate solutions as a function of concentr...