Nigella Sativa Oil Enhanced Motor Coordination in Phenol-Induced BALB/c Mice Models of Essential Tremor
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Background: Essential tremor is a neuronal disorder characterized by uncontrollable tremor of different body parts. Nigella sativa is an established therapeutic plant in various ailments including neurological disorders. This study evaluated the therapeutic roles of Nigella sativa oil on cerebellar phenotypes in phenol-induced mice model of essential tremor, through neurobehavioral, neurochemical and histological assays. Methods: Seventy-five (75) adult male BALB/c mice weighing 25±5g were equally divided into 5 groups. They were administered with either feed and water only (CTRL); 100mg/kg body weight (bw) phenol and 1ml/kgbw Nigella sativa oil concurrently (PNSC); 100mg/kgbw phenol (P); 1ml/kgbw Nigella sativa oil followed by 100mg/kg/bw phenol (NSP), or 1ml/kgbw Nigella sativa oil only (NS).Tremor response, body weight, temperature, motor coordination (using the parallel bars and static rods tests), relative brain weights, cerebellar glutamate and glutathione peroxidase (GPX) and histoarchitecture were assayed in the animals. Statistical analysis was carried out using one-way ANOVA at P<0.05. Results: The PNSC, NSP and NS mice decreased in weight. Histoarchitectural defects, relatively unchanged weight, increased GPX and glutamate levels and poor motor coordination were exhibited by the P group. The CTRL and NS animals demonstrated good motor coordination while the PNSC and NSP animals performed significantly better than the untreated group (P). The CTRL group showed no histoarchitectural defects while the NSP and PNSC animals showed improved histoarchitecture through increased neuronal sizes, densities and neuropiliary staining. Conclusion: This research affirmed the weight reducing, neuroprotective, neuroregenerative and motor coordinative effects of Nigella sativaoil in the modelled tremor condition.
Authors and Affiliations
R. O. Folarin, O. B. Surajudeen, E. O. Omotosho, A. O. Owoniyi, O. N. Asaye, D. O. Oyeleye, O. E. Keshinro
Keywords
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- EP ID EP677912
- DOI 10.29088/GCNR-2020.03
- Views 292
- Downloads 0
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