Ocular Surface Squamous Neoplasia Impression Cytology V/S Histopathology
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 1
Abstract
Ocular Surface Squamous Neoplasia (OSSN) is spectrum of conjunctival and corneal epithelial neoplasia manifesting as dysplasia, carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC). OSSN has a wide geographical variation, ranging from 0.13 to 1.9 per 100,000 population. Males are affected more often than females. The average age is usually sixth and seventh decade. The abnormal maturation of neoplastic cells is reflected in the morphology of the surface cells and their study forms the underlying principle of cytology. In impression cytology, either cellulose acetate paper or Biopore membrane is used for sampling. The study was conducted between June 2008 and May 2013.The study included 170 eyes of 168 patients. Biopsies from 168 patients found to have histologically proven OSSN are included in the study. On cytomorphology 130/170 specimens (76.4%) correlated with histopathology. Histological spectrum showed well differentiated SCC 34(33.3%) moderately differentiated SCC 53(51.9%) and poorly differentiated SCC 15(14.7%). Recurrence was seen in 31 cases (18.4%) at the limbus. OSSN occurs in the sun exposed areas of the conjunctiva at the limbus in elderly individuals. Impression cytology(IC) employing biopore membrane accurately predicts the histological diagnosis of (OSSN) with a high correlation rate of 76.4%. Histological spectrum showed more of invasive than Non invasive lesions. Impression cytology is a simple, non invasive technique with a high correlation rate in the diagnosis of OSSN. It is especially useful in patients with suspected recurrence following excision biopsy. Keywords: Ocular Surface Squamous Neoplasia, Impression cytology, Limbus, Biopore membrane, Dysplasia, Squamous cell carcinoma
Authors and Affiliations
Kavitha Toopalli, Vivekanand Namala, Modini Pandharpukar, N Bharadwaj, S. Jayalaxmi
Keywords
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