OESTROGEN, PROGESTERONE & HER2/NEU RECEPTOR STATUS IN PATIENTS WITH BREAST CARCINOMA WITH SPECIAL REFERENCE TO TRIPLE NEGATIVE STATUS IN A TERTIARY CARE HOSPITAL IN SOUTHERN ODISHA
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 12
Abstract
BACKGROUND Breast carcinoma is the most frequently diagnosed cancer and cause of cancer related deaths among women worldwide. Triple negative breast carcinoma (TNBC) is a subtype with poor outcomes. The current study aimed at evaluating the hormone receptor and HER2/neu status of the study population and to know the burden of triple negative breast carcinoma here. It also aimed at assessing TNBC’s response to various treatment modalities. MATERIALS AND METHODS In this prospective single institutional study, ninety-two new cases of breast carcinoma were diagnosed, treated and evaluated using HP study and IHC taking into consideration various parameters like age, tumour size, grade, lymph node involvement, ER/PR status, HER2 /neu status and response to treatment at 6 months of follow-up. RESULTS In this study, 78.2% cases were found to be Invasive Ductal Carcinoma (NOS) type. Oestrogen receptor positivity was seen in 48 (52.1%) cases. Progesterone receptor positivity was seen in 45 (48.9%) cases. HER2/neu positivity was seen in 36 (39.2%) cases. There were 45 (48.9%) patients in the study who showed both ER & PR positivity. The burden of triple negative cases was 31 (33.7%). CONCLUSION The current study revealed that the burden of the TNBC was high in the study population and outcomes for such cases were poor.
Authors and Affiliations
Sushanta Kumar Das, Rakesh Kumar Nayak, Niranjan Sahoo, Sanjeeb Kumar Pradhan, Saket Saurabh, Pranab Kumar Prusty, Ashis Patra, Manjulkanta Padhan
Keywords
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- EP ID EP615649
- DOI 10.18410/jebmh/2019/202
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