Abstract

Objective: Fungal are responsible for many infectious disease today and continue spreading. The frequency and severity have been growing at an alarming rate for years despite the existence of many drugs. In view of this pathetic situation, it is necessary to develop new active molecule from medicinal plants available and used in the traditional environment. Thus our study on the antifungal activity of Terminalia catappa on the in vitro growth of Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes was embarked upon. Approch experimental: To achieve this, nine extracts comprising of, two total extracts (aqueous and hydroethanolic 70%), six extracts from liquid-liquid partition of the ethanolic extract and chromatographic fraction F12 was made and tested. The tests were carried out on Sabouraud agar double dilution method in slope tubes. Results and discussion: All these extract tested are active, more or less pronounced on the three fungal isolates. Among these extracts, the butanolic extract (X3.1) was the least active extract and F12 fraction the most active extract. Regarding fungal isolates, Trichophyton mentagrophytes (MFC=0.5 μg/mL) was the most sensitive germ to F12 fraction and Aspergillus fumigatus the least sensitive (MFC= 10 μg/mL). As for Candida albicans, it was inhibited by F12 fraction at a value of MFC = 5 μg/mL. Conclusion: The chromatographic extract (fraction F12) is most active extract

Authors and Affiliations