Oral Chloroquine Induced Toxic Epidermal Necrolysis: A Rare Case Report
Journal Title: Scholars Journal of Medical Case Reports - Year 2016, Vol 4, Issue 7
Abstract
Toxic Epidermal Necrolysis (TEN) is an uncommon but acute life-threatening idiosyncratic mucocutaneous syndrome characterized by widespread epidermal necrosis followed by epidermal detachment. The average annual incidence of Toxic Epidermal Necrolysis is about 0.4-1.3 cases per million population and the mortality rate is about 25-30%. Drugs are considered to be the most common causative agents for 80-95% cases of drug induced TEN. Here, we report a case of a 35 years old female diagnosed for Malaria presented with the picture of adverse drug reaction of Toxic Epidermal Necrolysis due to oral Chloroquine given by the local physician. The patient was managed with Antibiotics, Corticosteroids and Intravenous fluids and recovered well within 25 days of admission from this fatal drug reaction. Since such cases have been rarely reported, we are intended to notify about this potentially dangerous drug reaction due to Chloroquine which is used extensively in the treatment of Malaria Keywords: Toxic Epidermal Necrolysis (TEN), adverse drug reaction, Chloroquine.
Authors and Affiliations
Dr. Sonali Suresh Kirde, Dr. Sushil Kumar Varma, Dr. Sarju Raghunath Zilate, Harshada Arun Bhoware
Keywords
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