Permissiveness Paradox in Cell Cycle Progression Towards Genome Instability and Malignant Transformation
Journal Title: Open Access Journal of Oncology and Medicine - Year 2018, Vol 2, Issue 2
Abstract
Dimensional representation of events actively executing the cell cycle dynamics of progression in carcinogenesis allow for a paradoxical emergence of highly permissive elements in the establishment of the mitotic spindle and the separation of chromatids. In such terms, ongoing processes of dissolution of the nuclear membrane betray an essential permissiveness in cell cycling that is paramount constitutional characterization of a process as “passenger” event in defining malignant transformation. In real terms, incremental progression of the cell cycle is specific hallmark for the events that constitutionally permit the system machinery in mitosis to conclusively establish potential re-setting of events as non-re-replication of the cell cycle in the re-emerging G1 phase of mitotic activity. The cell cycle dynamics and its relative interactions with states of instability of the genome acquire significant relevance in regard to cellular malignant transformation. There appears to be a tumor suppressor role effect of apoptosis, DNA repair by homozygous recombination and cell cycle arrest in G2 in simple epithelia subject to ionizing radiation-induced DNA damage [1]. The attributes of such interface effects include the dimensional shifts in phosphorylation of the retinoblastoma suppressor gene activities in a manner that prevents re-replication of the nuclear DNA within the same cell cycle. Such processes are linked to inhibitory effects of phosphorylation in relative measure to rephosphorylation. The dimensional connotations relative to genomic instability underlie progression of a cell-cycle series of events relative to the stabilization of CDK1/Cyclin B1 that progresses as alternate modes of representation and constitution of the cell replicative machinery components. In such measure, the inclusion of integral genomic participation in each of the cell cycle stages allows for phosphorylation and other post-translational events to assume transforming attributes to stage identity and potential.
Authors and Affiliations
Lawrence M Agius
Keywords
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- EP ID EP589078
- DOI 10.32474/OAJOM.2018.02.000133
- Views 51
- Downloads 0
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