Plasma adrenomedullin levels in patients with migraine during natural attack and attack free period
Journal Title: Medical Science and Discovery - Year 2016, Vol 3, Issue 4
Abstract
Objective: The role of Calcitonin G related peptide (CGRP) in migraine has been demonsrated. The aim of this study was to examine the role of Adrenomedullin (AM) which is a member of the calcitonin/CGRP/amylin family in migraine patients during naturel attack and attack free period.Material and Methods: 26 migraine patients (11 with aura, 15 without aura) and 26 healty participants were involved. Blood samples were obtained from each patient in attack and attack free period, then compared with each other and control group.Results: Mean plasma AM levels were 18.95 pmol/L during migraine attacks, 26.01 pmol/L between attacks, and 33.38 pmol/L in the control group. AM levels of migraine patients were significantly lower than controls during non-attack periods (p=0.001) and more interestingly, it further decreased during attack periods (p=0.001). A comparison of the mean plasma AM levels of migraine with and without aura cases revealed the same statistically significant difference (p=0.00).Conclusion: The persistently low AM levels in migraine patients gave the impression that in physiological conditions there may be a balance between CGRP and AM and this may be changed towards to the site of CGRP in migraine pathophysiology while causing a decline in AM levels as we had found. Further studies regarding on AM involvement in migraine pathophysiology are needed to confirm these results.
Authors and Affiliations
Aylin Akcali, Sirma Geyik, Ilker Dogru, Arzu Dogru, Muhittin Yurekli, Abdurrahman Neyal, Ayse Balat, Munife Neyal
Effect of heavy metal and some trace element levels on radiotherapy taken breast cancer patients
Objective: The aim of this article is to research the effects of radiotherapy on trace elements and heavy metals in patients with breast cancer. Breast cancer is a common disease worldwide. Breast cancer risk increases...
Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains
Objective: The most important problem in the treatment of nosocomial Acinetobacter baumannii (A. baumannii) infections which is increasingly seen in recent years is that almost all strains are resistant to man...
Anaplastic Childhood Meningioma in a 16-Year-Old Boy
Introduction: Meningiomas account for 0.4-4.6% of all primary brain tumors in children. Childhood meningiomas have several different characteristics than those occuring in adults. Case: Here we report a 16 year old male...
Should the chronic form of tularemia be defined? Should the treatment of the chronic form be managed differently?
Background: Tularemia is a bacterial, zoonotic disease caused by Francisella tularensis. Although the ulceroglandular form is the most common form in the world, oropharyngeal tularemia is the most common form in Turkey...
Does 18F FDG PET/CT paramaters predict histopathologic response to the neoadjuvant therapy in patients with non-small cell lung cancer?
Objective: Progression-free and overall survival are better correlated with metabolically active tumor volume (MTV) and total lesion glycolysis (TLG), as compared to the maximum standardized uptake value (SUVm...