POLYMORPHISM IN PHARMACEUTICALS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 8
Abstract
Polymorphism is the phenomenon in which a drug substance can exist in either two or more than two crystalline forms with different physicochemical properties. Obiquity and importance of Polymorphism occurring in pharmaceutical compounds are well recognized. It is very important and crucial to select the right polymorphic form from the beginning of drug discovery and drug development. While formulating a drug product, solubility, stability and bioavailability of API are the prominent factors. To manipulate this factors, study of study of polymorphism is essential which will give a knowledge on rapid absorption of BCS class-II, IV drugs in systemic circulation. For this, it is important to characterize each form of the drug with suitable analytical techniques. This review will give an insight information about the different properties, preparation, stability and application of different polymorphic forms with some examples of classical drugs. This will help to acquire an overall knowledge about Polymorphism in Pharmaceuticals.
Authors and Affiliations
Dinesh Choudhury
Keywords
Related Articles
- EP ID EP627662
- DOI -
- Views 135
- Downloads 0
ASSESMENT OF PLASMA RANDOM BLOOD GLUCOSE AND GLYCATED HAEMOGLOBIN LEVELS IN HYPERTENSIVE SUBJECTS IN SOME HOSPITALS IN ANAMBRA STATE, NIGERIA.
Hypertension is an important and major global public health problem.This study is designed to assess plasma random blood glucose and glycated hemoglobin levels in hypertensive (non-diabetic) subjects in some hospitals in...
THE ANTIBACTERIAL EFFECT OF FLAXSEED EXTRACT ON SELECTIVE ORAL PATHOGENS - COMPARATIVE IN VITRO STUDY
Introduction: Flaxseed from the flax plant (Linum usitatissimum), which has been cultivated for domestic use since prehistoric times. This study aims to investigate presence of antibacterial effect of flaxseed extract ag...
THE SUBSTANTION OF THE TABLET MASS “AMBROL” COMPOSITION CHOICE FOR TABLETIZING
Non-narcotic drugs are divided into two main groups. First group includes drugs of central action for instance, butamiratome, glaucine, ledin, pentoxiverin, okseladin and folkodinom; second group includes drugs that have...
A REVIEW ON THE PREPARATION OF VINEGAR FROM FRUIT PEELS.
Vinegar is the product obtained exclusively through biotechnological processes such as double fermentation, alcoholic acetic fermentation of the liquid. There are various types of vinegars obtained from various sources s...
AWARENESS OF HEPATITIS C IN KARACHI, PAKISTAN
Objective: Hepatitis C is the infection of liver caused by hepatitis C virus. Many people who are infected with this virus have lack of awareness regarding this disease. Methodology: A descriptive study was conducted aim...