Potential possibilities of using selected biologically-active substances in supporting pharmacological treatment of Crohn’s Disease – Review of trial results

Journal Title: Medycyna Ogólna i Nauki o Zdrowiu - Year 2015, Vol 21, Issue 4

Abstract

[b]Introduction.[/b] Crohn’s Disease (CD) is a chronic and incurable, inflammatory bowel disease, that is characterized by periods of remissions and relapses. An improper diet may impair nutritional status, exacerbate the symptoms and shorten the duration of remission. The to-date dietary recommendations for the patients concern mainly the reduction of intake of the products that exacerbate the symptoms, as well as combating malnutrition. [b]Objective.[/b] Review of the literature concerning the possibility of using certain biologically- active substances in supporting pharmacological treatment of Crohn’s Disease. [b]Scientific knowledge.[/b] Certain substances, such as polyunsaturated fatty acids n-3, glutamine, probiotics, prebiotics and short-chain fatty acids may exhibit anti-inflammatory properties, primarily by regulating the number and composition of physiological gut microflora and inhibiting the expression of proinflammatory cytokines. Although the beneficial effects of using biologically-active substances have been confirmed in many in vitro and in vivo animal studies, the results of studies in humans are unclear. However, in most studies it has been revealed that those substances, despite their ineffectiveness, are probably safe and their use is not associated with an increased risk of side effects or exacerbation of patient›s condition. [b]Conclusion.[/b] Therapy with the above-mentioned substances is not used for treatment Crohn’s Disease and the results of studies are inconclusive. Therefore, other studies with polyunsaturated fatty acids n-3, glutamine, probiotics, prebiotics and short-chain fatty acids are needed in order to determine their effectiveness on the treatment of Crohn’s Disease.[b]Key words[/b]: Crohn’s Disease, polyunsaturated fatty acids n-3, glutamine, probiotics, prebiotics, short-chain fatty acids

Authors and Affiliations

Anna Czekajło, Dorota Różańska

Keywords

Related Articles

Analysis of selected variables determining the occurrence of postpartum depression

[b]objective[/b]. Evaluation of the intensity of mood disorders a week after childbirth, and determination of the effect of obstetric-gynaecological factors determining the occurrence of postpartum depression. [b]materia...

Differences in the state of health of rural and urban inhabitants in the Lublin region

The state of health of rural and urban population in the Lublin Region was analysed with the use of the values of measures from 2006. The health status of the rural population in this region is, from many aspects, worse...

Family system and cancer – selected issues

The family is the fundamental unit of society, a system made up of components that together form a whole. The appearance of cancer in the family completely changes the life not only of the patient but also the whole syst...

Non-pharmacological treatment of patients with dementia

In the practice of a family physician, ageing society means an increasing number of patients suffering from Alzheimer’s disease or other forms of dementia. Pharmacological treatment slows down the process of neurodegener...

Care for health in opinions of students of Physical Education and Public Health from colleges in Biała Podlaska

Care for health and pro-health behaviour are the basic issues of education and health promotion. Family, school and the milieu of peers contribute greatly to shaping the attitude. Professional passing of knowledge on hea...

Download PDF file
  • EP ID EP79481
  • DOI 10.5604/20834543.1186903
  • Views 103
  • Downloads 0

How To Cite

Anna Czekajło, Dorota Różańska (2015). Potential possibilities of using selected biologically-active substances in supporting pharmacological treatment of Crohn’s Disease – Review of trial results. Medycyna Ogólna i Nauki o Zdrowiu, 21(4), 346-351. https://europub.co.uk/articles/-A-79481