Prednisolone with Artesunate Effect on Henoch Schonle in Purpura with Malaria Condition

Journal Title: Journal of Clinical and Medical Research - Year 2019, Vol 1, Issue 3

Abstract

Topical analgesics are regarded as new inroads to treat peripheral neuropathic pain, with a number of advantages over oral treatments. Topical treatment reduces systemic induced side-effects and have good tolerability, without problems of misuse or abuse, or dependency. Furthermore, the onset of action is fast, mostly within 30 minutes. The mechanism of action of topical analgesics is either via transdermal delivery of the analgesic, or via intradermal mechanisms of action. In the latter case, plasma levels of analgesics in the blood are absent or very low. This perspective is missing in the approach of the ad hoc committee of the National Academies of Sciences, Engineering, and Medicine in the USA, installed by the FDA. In this short commentary, we plead for a more comprehensive approach of topical analgesics, including those formulations which explicitly are not based on transdermal penetration of the active pharmaceutical ingredient, but on intradermal mechanisms of action.

Authors and Affiliations

Jan M Keppel Hesselink*

Keywords

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  • EP ID EP708375
  • DOI https://doi.org/10.37191/Mapsci-2582-4333-1(3)-017
  • Views 62
  • Downloads 0

How To Cite

Jan M Keppel Hesselink* (2019). Prednisolone with Artesunate Effect on Henoch Schonle in Purpura with Malaria Condition. Journal of Clinical and Medical Research, 1(3), -. https://europub.co.uk/articles/-A-708375