Preparation and drug release assessment of mesalazine matrix tablets
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2014, Vol 2, Issue 1
Abstract
The major objective is to develop colon targeted drug delivery system by using Chitosan, Eudragit S 100 and Ethylcellulose and to compare the results obtained by three different carrier systems. Results obtained were fitted to different mathematical models to estimate which model fits best to the drug release. Wet granulation technique was employed for the preparation of prolonged release matrix tablets. Tablets containing chitosan as carrier system were found to show prolonged release in the colon. Kinetic models were applied among which Higuchi model suits best.
Authors and Affiliations
Satinder Kakar, Ramandeep Singh, Ramandeep Kaur, Alok Semwal
Keywords
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