Prevalence of Anti-Tissue Transglutaminase IgA in Type 1 Diabetes Mellitus Patients Attending Al-Dewanyia Teaching hospital
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 8
Abstract
It has been shown that there was an association between celiac disease and type 1 diabetes mellitus due to shared immunological background, periodic serological screening is necessary for early diagnosis of celiac disease due to this relation. Thus, the objective is to study the prevalence of anti-tissue transglutaminase antibody IgA in patients with type 1diabetes. A total of 80patients with type 1 diabetes attending Dewanyia Teaching Hospital; 35 boys, 45 girls with mean age of 10.3 year± 3.7 and mean duration of diabetes3.5years ±2.5, from June 2013 -June 2014 were screened for anti-tissue transglutaminase IgA. The present study found that the, Anti- tissue transglutaminase antibody was positive in 13 patients, more in girls (68%), making the prevalence of celiac disease about8.6%. The classical presentation of the disease was lacking in mostpatients, but they presented with short stature which was below the third percentile in 79% of patient with celiac disease. In most cases Celiac disease was diagnosed within the first year of diabetes diagnosis. Thus, we concluded that Annual autoantibody screening is recommended, for early diagnosis and management of patients with diabetes type 1. Keywords: Diabetes mellitus, celiac disease, anti-tissue transglutaminase antibody, celiac risk factor, anti-glutamic acid decarboxylase, DM leading celiac disease
Authors and Affiliations
Rateb F. Abo Khadher, Ibrahim Abdulmajeed Altamemi
Keywords
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