PREVALENCE OF CARBAPENEM RESISTANT ENTEROBACTERIACEAE- A STUDY IN A TERTIARY CARE HOSPITAL IN MUMBAI
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 45
Abstract
BACKGROUND The global incidence of carbapenem resistant organisms is on the rise and can be attributed to indiscriminate use of carbapenem to tackle the Extended Spectrum Beta Lactamase (ESBL) producing organisms. Carbapenem resistance is associated with resistance to other group of antibiotics. The spread of resistance from one bug to another is not uncommon. The organism persists in the hospital environment and is identified as cause of hospital-acquired infections. This is not only a major concern in the healthcare setting but is also increasingly being recovered from community settings also. Limited availability of drugs to treat these infections is the biggest concern. Identifying carbapenem resistant organisms and implementing measures to prevent the spread is need of the hour. The aim of this study is to determine the prevalence and susceptibility pattern of Carbapenem resistant Enterobacteriaceae. MATERIALS AND METHODS A descriptive study was carried out in the Department of Microbiology of a tertiary care teaching institute of Mumbai. All Enterobacteriaceae isolates recovered during the six months study period of January 2017 to June 2017 were included in the study. The isolates were identified using standard conventional biochemical methods. Antimicrobial susceptibility was performed using the Kirby-Bauer disc diffusion technique and interpreted as per CLSI 2016 standards. RESULTS A total of 442 isolates of Enterobacteriaceae were recovered during the study period. The different strains isolated included Escherichia coli (218), Klebsiella pneumoniae (161), Proteus spp. (42), Salmonella (9), Citrobacter spp. (1) and Enterobacter spp. (1); 107 out of 442 (24.2%) were Carbapenem resistant 18.8% of E. coli, 37.9% of Klebsiella pneumoniae. Maximum number of CRE were recovered from Medicine Department (34.1%). The least number of CRE isolates were recovered from ENT (5.8%). CONCLUSION The prevalence of Carbapenem resistant isolates is high in our settings. Strict adherence to infection control practices and stringent implementation of antimicrobial stewardship is essential to curb the rate of Carbapenem resistant isolates.
Authors and Affiliations
Sukanya Verma, Suyasha S. Thorat, Kishore Bisure
Keywords
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- EP ID EP550456
- DOI 10.14260/jemds/2018/1093
- Views 76
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