Prevalence of Hepatitis C in alcoholic liver disease.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 3
Abstract
Alcohol consumption and hepatitis C virus (HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play an important role. Traditionally, HCV prevalence has been considered to be higher (up to 50%) in alcoholic patients than in the general population. Due to the toxic combined effect of HCV and alcohol, patients with HCV infection should be screened for excessive ethanol intake. Patients starting treatment for HCV infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefit from additional support during antiviral therapy. This recommendation might be extended to all currently recommended drugs for HCV treatment. In Our study on 194 patients of ALD, we found anti Hcv ab was positive in 18.6% of patients of ALD. Most of cases had developed cirrhosis and its complications. Of all Anti HCV Ab positive patients 55.6% presented with Gastrointestinal bleeding and 46.7% with Hepatic encephalopathy. The mean value of SGOT and SGPT were significantly higher in Anti HCV Ab positive patients as compared to Anti Hcv ab negative patients. The study concluded that alcoholics who are Anti HCV Ab positive are more prone to develop cirrhosis of liver with its various complication
Authors and Affiliations
Krishan Oberoi, Bhupinder Singh, Sat Pal Aloona N. S. Neki
Keywords
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- EP ID EP550050
- DOI 10.22192/ijcrms.2017.03.03.002
- Views 139
- Downloads 0
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