Prospective and observational study of antimicrobial drug utilization in medical intensive care unit in a tertiary care teaching hospital
Journal Title: International Journal of Pharmacological Research - Year 2016, Vol 6, Issue 1
Abstract
Objectives: 1) The objective of this study was to assess the prescribing patterns of anti-microbial drugs. 2) Rationality of drug use in the medical ICU of a tertiary care hospital. Materials and Methods: After taking approval from the Institutional ethical committee, study was undertaken over a period of 6 months. A prospective observational study was conducted to assess the prescription pattern of antibiotic usage in the medical ICU. Standard Proforma was used to collect the information regarding antibiotics, its dose, duration, first line of antibiotics and second line of antibiotics and adverse drug reactions. Data was analysed using descriptive statistics with help of SPSS software. Results: Total 202 cases were admitted to the ICU during study period. Respiratory conditions (33.2%), febrile illness (15.3%), poisoning (15.3%) and CNS (12.9%) illnesses were commonly reported to ICU. Cephalosporins (81.7%) were commonly prescribed followed by Nitroimidazoles (30.2%) and Penicillin (16.3%). Ceftriaxone (43.1%) and cefixime (38.6%) were commonly used followed by Pipercillin + Tazobactum combination (9.4%). No adverse reactions were reported during the study period. Conclusion: In conclusion, a wide spectrum of clinical diagnoses and a variety of drugs were utilized from various drug classes. Results showed that Cephalosporins were extensively used in ICU. The number of drugs prescribed by generic names was low in the ICU and effort must be made to encourage prescribing by generic names. Rational usage of antimicrobial agents in ICU should be encouraged by following strict Hospital antimicrobial policy.
Authors and Affiliations
Drupad HS, Nagabushan H, Prakash GM
Keywords
Related Articles
- EP ID EP435138
- DOI 10.7439/ijpr.v6i1.2886
- Views 61
- Downloads 0
Effect of Gymnema sylvestre on the pharmacokinetics and pharmacodynamics of 0.5mg & 0.6mg Glibenclamide in diabetic rats
Traditional medicines derived from medicinal plants are used by about 60 per cent world population. Diabetes is an important human ailment officiating many from various walk of life in different countries including India...
Knowledge, Attitude and Practice of Adverse Drug Reactions Reporting Among Healthcare Professionals
Objectives: This study was conducted to evaluate knowledge, attitude and practice of Adverse Drug Reactions (ADR) reporting among Healthcare Professionals. Methods: A cross-sectional study was done by survey using quest...
Water extract of Osmanthus Fragrans attenuates TGF-?1-induced lung cellular fibrosis in human lung fibroblasts cells
Introduction: Idiopathic interstitial pneumonia, also known as idiopathic pulmonary fibrosis, is a type of diffuse parenchymal lung disease of unknown etiology. Osmanthus Fragrans, referred to as sweet olives, possesses...
Structural elucidation of novel bioactive compound (2-chloro-1-(2-chlorocyclopropyl)-2-(4-nitrophenyl)ethanone) from basidiomycetous fungus Lentinus squarrosulus
While screening for bioactive compounds from macrofungi of Western Ghats of Karnataka, Lentinus squarrosulus a member of polyporaceae was collected and mycelium of the fungus was obtained on potato dextrose agar medium a...
Prevalence of multiple pollutants in selected Tamil Nadu coastal waters, Southern India
The sea water samples from five different coastal cities (Chennai S1, Cuddalore S2, Nagappattinam S3, Tuticorin S4 and Kanyakumari S5) in Tamil Nadu were collected during premonsoon 2015 for physiochemical, microbiologic...