Pulmonary metastasis of Giant Cell Tumor of bone diagnosed by CT guided Fine Needle Aspiration with Histomorphological correlation
Journal Title: Perspectives In Medical Research - Year 2016, Vol 4, Issue 1
Abstract
Introduction: Giant cell tumor(GCT) comprises around 4-5 % of all primary bone tumors and has a peak incidence between 20 and 45 years of age. Despite being classified as benign, giant cell tumor is capable of locally aggressive behaviour and occassionally of distant metastasis. Pulmonary metastasis are seen in 2 % of patients with GCTs, on average 3-4 years after primary diagnosis. These may be solitary or multiple. Pulmonary metastases of the GCT may be affected by tumor grading and localization as well as age, gender and overall health status of the patient. Patients with local recurrences of GCT of bones are more likely to develop pulmonary metastases. High expression of some genes, cytokines and chemokines may also be closely related to the metastatic potential and prognosis of GCT of bones. Some of the pulmonary metastases of GCT of bones are very slow growing , some regress spontaneously and rarely lethal. Segmental resection is considered to be the most effective treatment of pulmonary metastases while chemotherapy and/or radiotherapy may be alternate treatments in unresectable cases. An early diagnosis of the tumor can be challenging due to its rarity and done by a CT scan followed by a CT guided FNAC.
Authors and Affiliations
Aurobinda Samal
Keywords
Related Articles
- EP ID EP299651
- DOI -
- Views 107
- Downloads 0
Initial experience of Extracorporeal shock wave lithotripsy with robotic navigation
Aim: The main aim was to retrospectively assess the results of treatment of upper urinary tract stones with the Sonolith vision manufactured by EDAP. Material and Methods: In this study 200 patients who underwent extra...
Hypovitaminosis-D in medical students: Unrecognized or Undertreated
Introduction: Vitamin D deficiency is a pandemic, non communicable disease in India and worldwide. Vitamin D, which is technically a hormone rather than a fat soluble secosteroid responsible for increasing intestinal abs...
Histopathological analysis of neoplastic and non neoplastic lesions of ovary: A study of one hundred cases
Background: The study was done to know the various histopathological variants in ovarian lesions, the age incidence of various ovarian lesions and to assess the frequency of unilateral and bilateral lesions. Materials a...
A rare case of right sided aortic arch with aberrant left subclavian artery
Introduction: A right-sided aortic arch is a rare congenital defect of the aorta. It is seen in approximately 0.1% of population. It is of 3 subtypes some of which are associated with cyanotic congenital heart diasease a...
Parenteral iron sucrose as an alternative to packed cell transfusion in moderate to severe anaemia in pregnancy
Introduction: Iron deficiency anaemia remains the most common medical disorder in pregnancy in the developing world, with the burden of disease impacting on both the mother and the new born. Packed cells\blood transfusio...