REGULATION OF WNT GENES IN STEM CELLS DEVELOPMENT AND ORGANOGENESIS

Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 6

Abstract

Stem cell biology, many signals regulated stem cells and organ development. Wnt factors play a crucial role in stem cells development and induced signaling pathway in stem cells. Wnt signals classified as a canonical and non-canonical pathway. Wnt factors regulated both pathways for stem cells self-renewal, proliferation, and differentiation. Wnt canonical pathway induced by Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt4, Wnt5a, Wnt6, Wnt7a, Wnt7b, Wnt8a, Wnt8b, Wnt10a and Wnt10b. Wnt non-canonical pathway regulated by Wnt factors such as Wnt1, Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, Wnt7b, Wnt9a, Wnt9b, Wnt10a, Wnt10b, Wnt11, and Wnt16. These all factors have a specialized role in stem cells and development. These factors also regulated wound healing mechanism and variety of organ regeneration. Finally, abnormality or aberrant expression of Wnt signals regulated a variety of cancers.

Authors and Affiliations

R. Prakash

Keywords

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  • EP ID EP554909
  • DOI -
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How To Cite

R. Prakash (2014). REGULATION OF WNT GENES IN STEM CELLS DEVELOPMENT AND ORGANOGENESIS. International Journal of Pharmacognosy, 1(6), 366-372. https://europub.co.uk/articles/-A-554909