Relationship between Serum Levels of Albumin and C - reactive protein (CRP) In Patients with Chronic Kidney Disease
Journal Title: Scholars International Journal of Biochemistry - Year 2018, Vol 1, Issue 2
Abstract
Protein- energy malnutrition, wasting and inflammation are frequent complication among patient with Chronic kidney disease (CKD). Malnutrition is associated with cardiac co-morbidity, inflammation and poor survival in CKD patients. Serum albumin is a well-known negative acute phase protein, marker of nutrition in CKD patients. C-reactive protein (CRP), the major acute phase response (APR) protein is elevated in these patients. High CRP levels are linked to the degree of atherosclerosis in coronary, peripheral, and extracranial brain arteries. The aim of the present study was to investigate nutritional factor (albumin) and CRP levels in CKD patients. This cross –sectional study was carried out in the Department of Biochemistry in collaboration with the Department of Medicine, Guru Gobind Singh Medical College & Hospital, Faridkot .Study involved 100 pre dialysis CKD patients (age 40.5 ± 12.3 years) admitted indoor and attending outdoor .Following investigations were carried out –CRP by fluorescence immunoassay method utilizing latex particles coated with CRP monoclonal antibodies (I-chroma). Serum albumin levels on fully automated chemistry analyzer Renal function by estimated glomerular filtration rate (eGFR). The data was later statistically analyzed. The study patients included 57 males (57%) and 43 females (43%) with average age of 40.5±12.3 years. The mean GFR was 38.3 ± 16.4 ml/min/1.73m2. The mean value of CRP was 10.93 ± 1.42 mg /dl. 67% of patients had elevated CRP (> 6 mg/L) with low serum albumin levels were present with mean value (3.02 ± 0.17 gm/dL). This study showed that low albumin and high CRP levels are the main predictors for death. There was a significant difference between CRP and albumin levels in CKD patients (P<0.001). Measuring CRP as a marker of inflammation can be helpful in managing these patients and Low levels of albumin are a marker of poor nutritional status in CKD patients. Our results indicate that CRP(as marker of inflammation) and albumin(as marker of nutritional status ) were very closely related to each other ,as the levels of CRP increased the albumin goes on decreasing due to degree of inflammation , malnutrition and decreased synthesis by liver exists in pre-dialysis CKD patients.
Authors and Affiliations
Kirti . , Sumit Kumar, Gitanjali Goyal, Cheenu Garg
Keywords
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