RELATIONSHIP BETWEEN THE STRUCTURAL-FUNCTIONAL STATE OF VESSELS AND METABOLIC DISORDERS IN PATIENTS WITH GOUT AND ESSENTIAL HYPERTENSION
Journal Title: Молодий вчений - Year 2017, Vol 10, Issue 50
Abstract
Uric acid (UA) is a product of metabolism and has a multi-faceted effect on the whole body. The purpose of the study was to study the effect of UA on the structural and functional state of brachiocephalic vessels, vascular and motor function of the endothelium and lipid spectrum in patients with gout, in combination with hypertension. The study included 140 males and divided into three groups: I (n = 40) – patients with hypertension; ІІ (n = 20) – patients with gout; III (n = 80) – patients with gout and hypertension. All patients underwent ultrasound examination of major vessels of the head and neck, a test for the detection of endothelial dysfunction and biochemical studies to study the lipid profile and the oxidative-reduction system of the blood. As a result of the study, it was shown that patients with gout and hypertension have significantly lower structural and functional parameters of the major vessels, the lipid spectrum with the development of atherosclerosis compared with other patients. The main predictors of the appearance of structural and functional vascular disorders in patients with gout with hypertension are the level of UA and the concentration of superoxiddismutase.
Authors and Affiliations
I. P. Synytsia
Keywords
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