Research progress on protein glycosylation modification in ocular diseases
Journal Title: Eye Science (Yanke Xuebao) - Year 2024, Vol 39, Issue 4
Abstract
Glycosylation is an important post-translational modification of proteins that usually occurs at specific locations within the endoplasmic reticulum and Golgi apparatus. N-glycosylation and O-glycosylation are the most common types of glycosylation modifications. Compared to other post-translational modifications, glycosylation has unique biological significance, including structural complexity and diversity, crucial biological functions, and evolutionary conservation. Glycosylation modifications significantly impact protein stability, cell adhesion and recognition, intracellular signal transduction, and epigenetics, thereby regulating cellular biology and pathogenesis. In recent years, an increasing amount of research has revealed the involvement of glycosylation in the occurrence and development of ocular diseases, including ocular surface diseases, keratoconus, glaucoma, age-related macular degeneration, retinitis pigmentosa, and diabetic retinopathy. Abnormal glycosylation of ocular proteins can induce changes in cell structure and function through mechanisms such as neovascularization, inflammatory response, oxidative stress, and abnormal immune response, thereby influencing the occurrence and development of various eye diseases. By deeply studying the mechanisms of glycosylation in different ocular diseases, new insights and methods can be provided for the early diagnosis and treatment of related ocular diseases. This review summarizes the research progress of glycosylation in ocular diseases to explore the diagnostic and therapeutic significance of regulating protein glycosylation in ocular diseases.
Authors and Affiliations
Zhuqing ZHENG, Keran LI, Wen BAI
Keywords
Related Articles
- EP ID EP764745
- DOI 10.12419/24050603
- Views 23
- Downloads 0
Diagnosis of central serous chorioretinopathy complicated with choroidal neovascularization by multi-mode imaging technology: A case report
Central serous chorioretinopathy (CSC) is a common diseasein clinical practice. In recent years, CSC complicated with choroidal neovascularization (CNV) cases have been reported. In this article, we applied multi-mode im...
Prospect of application of artificial intelligence and block chain in the information construction of Biobank
In recent years, artificial intelligence (AI) technology has been applied to analyze clinical big data and images and then make intelligent diagnosis, prediction and treatment decisions. It is gradually becoming an advan...
What are the highlights of glaucoma prevention and treatment in China in the future?
Glaucoma is the first irreversible blinding eye disease in the world. How to detect early, diagnose timely, treat appropriately and adhere to follow-up management has always been the direction of Chinese ophthalmic clini...
Differences of biochemical indicators and optical coherence tomography angiography in patients with different degrees of diabetic retinopathy
[Objective:] To explore the applications of optical coherence tomography angiography (OCTA) in diabetic retinopathy. [Methods:] A total of 63 diabetic patients in the Department of Ophthalmology, Seventh Affiliated Hospi...
Glaucoma secondary to congenital ectropion uveae: case series report and literature review
[Objective:] To analyze the clinical manifestations, imaging characteristics, and treatment methods of secondary glaucoma associated with congenital ectropion uveae (CEU). [Methods:] Observational case series and literat...