Results of exchange transfusions in newborns without blood group incompatibility

Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 2


Objective: Hyperbilirubinemia is a common problem of neonatal period that has high morbidity and mortality. Blood exchange is the most effective and urgent treatment modality for very high bilirubin levels that can lead to neurotoxicity called as kernicterus. The aim of this study was to compare 90 minutes exchange transfusion with that of 120 minutes. Methods: This study was performed at Dicle University Medical Faculty, Neonatal Unit between July 2007 and June 2008. A total of 36 term newborn (38 - 42 gestational week) without blood group incompatibility and with total serum bilirubin levels over 25 mg/dl were included. Newborns were randomly assigned in two groups each of them comprise 18 babies as Group 1 underwent 90 minute-exchange and Group 2 120 minute. Effectiveness and complications of exchange transfusion were recorded. Newborns with Rh, ABO or subgroup incompatibilities, prematurity or small for gestational age, septicemia, hypothyroidism, G6PD enzyme deficiency, intrauterine infections, diabetic mother’s baby, hemolytic disease or metabolic diseases were excluded. Results: There were no significant differences in the body weight, gestational age, postnatal age, age of mother, total bilirubin and albumin levels, the number of blood exchange, hospital stay days and complications between two groups (p>0.05). However, mean phototherapy duration was significantly shorter in 120 minutes transfusion group compared with 90 minutes group (p<0.001). Conclusion: Our results indicated that 90 minutes was sufficient for an effective exchange transfusion in severe hyperbilirubinemic newborn infants. However longer exchange transfusion durations may shorten the duration of phototherapy. Key words: Indirect hyperbilirubinemia, exchange transfusion, newborns, outcome

Authors and Affiliations

Servet Yel, Selvi Kelekçi, Çapan Konca, İlyas Yolbaş, Velat Şen, Selahattin Katar


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  • EP ID EP87513
  • DOI 10.5798/diclemedj.0921.2013.02.0260
  • Views 71
  • Downloads 0

How To Cite

Servet Yel, Selvi Kelekçi, Çapan Konca, İlyas Yolbaş, Velat Şen, Selahattin Katar (2013). Results of exchange transfusions in newborns without blood group incompatibility. Dicle Tıp Dergisi, 40(2), 231-236.