Role of Autologous Stem Cell Therapy in Asherman’s Syndrome and Thin Endometrium: A Case Series
Journal Title: Scholars Journal of Medical Case Reports - Year 2017, Vol 5, Issue 5
Abstract
Stemcells are the cells that perpetually produce another alike cells (self renewal) and have the capacity to differentiate in to diverse cell types if need arise, in all multi-cellular organisms for repair and regeneration of damaged tissue. Lately group of epithelial progenitor cells and mesenchymal stromal cells were found to be responsible for regenerating the functional layer of endometrium after menstruation and parturition. Any injury, surgery, trauma, or infection can damage to the endometrial lining thus causing scarring and fibrosis of endometrium along with thinning of endometrium which is known as Asherman’s syndrome. Thus transplantation of mesenchymal stem cells[MSCs] and hematopoietic stem cell[HSCs] in the uterus along with growth factors will help in regeneration of endometrium with healing of fibrosis.The purpose of this study is to evaluate whether autologous stem cell transplantation in uterus may improve endometrial thickness and reduce scarring in case of Asherman’s syndrome. Five married women with secondary sterility with amenorrhoea in 2 patients and scanty and irregular menses in 3 patients due to endometrial factorwere selected on the basis of clinical features and investigations, who have been treated for Asherman’s syndrome by different modalities with no avail and were, advised surrogacy. MSCS & HSCs were implanted at endometrial (basal layer) myometrial junction, at 3- 4 sites, Endometrial response was assessed by USG at monthly interval. All 5 patients got relief in term of resuming menstruation, in 2 amenorrhoeicpt; rest 3 patients have improvement in menstrual flow. Adult Autologous MSCs & HSCs transplantation in uterus helps in reversal of chronic inflammatory changes with re-growth of endometrium, in turn improved symptoms & prospect of fertility. Keywords:Adult autologous stem cells, MSCs, HSCs, endometrial regeneration, Asherman’s syndrome, growth factors
Authors and Affiliations
DrSapna Jain, DrMayank Jain, DrAstha Gupta, DrMannan gupta, DrPoonam Verma
Keywords
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