Role of Serum Leptin and its association with Malondialdehyde in Type 2 Diabetic Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Background: Leptin is a hormone produced by adipose tissue that regulates a number of physiological processes and behaviors including appetite, body weight, neuroendocrine functions and glycaemia. These effects are mediated via actions on leptin receptors (LepRs) expressed by neurons in the central nervous system (CNS). Aim: The aim of this study was to evaluate the significance of leptin levels in T2DM patients compared with controls and to determine the association of leptin with malondialdehyde (MDA) Materials and methods: Thirty T2DM patients with the age group of 35 to 50 years were selected for this study and 30 healthy age matched subjects were selected as a control group. Serum leptin was assessed by ELISA, malondialdehyde (MDA) was assessed by Thiobarbituric Acid Reactive Substances (TBARS) method and routine investigations were done by ERBA EM-360 fully automated analyzer. Results: The mean level of serum leptin was significantly increased in T2DM patients compared with controls. Serum leptin levels were positively correlated with FPG, PPG, HbA1c, Homeostasis model assessment of insulin resistance (HOMA-IR), malondialdehyde, Cholesterol, TGL, LDL, BMI and negatively correlated with HDL. Conclusion: Leptin might be useful diagnostic marker for the severity of inflammation, chronicity of the disease and vascular complications.
Authors and Affiliations
Santhi. T, Keerthana. B, Anil Kumar. T, Balu Mahendran. K
Keywords
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- EP ID EP588805
- DOI 10.9790/0853-1601034346
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