Serum Ceruloplasmin and Serum Adenosine Deaminase: Do They have a Role as a Noninvasive Diagnostic and follow Up Adjuncts in Malignant Solid Tumors?
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Ceruloplasmin is an acute phase reactant, the levels of which fluctuate in response to tissue injuries of various kinds. Adenosine deaminase enzyme on the other hand through purine salvage system is involved in various cellular proliferations. Increased ceruloplasmin and adenosine deaminase activity may be of significance in neoplastic disorders with increased cell turnover. ADA has been evaluated in pleural and ascitic fluids extensively but relatively there are fewer serum ADA studies in malignancy. Serum ceruloplasmin has been assessed as an acute phase reactant in inflammatory conditions but its role in malignancy is still under explored. Aim of this study was to assess the clinical utility of serum ceruloplasmin and serum adenosine deaminase as diagnostic and follow up tools in malignant solid tumors. Material and methods: Serum concentrations of ceruloplasmin and adenosine deaminase were determined in 100 consecutive cases of solid malignant tumors, at diagnosis and at four weeks after surgical resection of tumor. Samples from 100 healthy young individuals were taken as control. Results: Serum ceruloplasmin and adenosine deaminase levels were significantly higher in patients compared to the healthy control group. The enzyme parameters showed decrease trend after surgery, however the fall in serum adenosine deaminase level in malignant tumors was found statistically significant. Conclusion: Serum ceruloplasmin and adenosine deaminase can be used as adjuncts in the diagnosis of various solid malignant tumors. Serum adenosine deaminase may also be useful as a follow up tool in malignant tumors
Authors and Affiliations
Pratibha Misra, Arijit Kumar Ghosh
Keywords
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