Serum interleukin-6 and mean platelet volume in pediatric pneumonia
Journal Title: Paediatrica Indonesiana - Year 2016, Vol 56, Issue 1
Abstract
Background In pneumonia, interleukin (IL)-6 is released in response to inflammation. Interleukin-6 stimulates megakaryocyte maturation, leading to larger platelets being released into the circulation. Platelet size is measured as mean platelet volume (MPV). The MPV may also be affected by nutritional status and smoking.Objective To assess for a possible relationship between serum IL-6 concentration and MPV, including smoking and nutritional status as confounding factors, in children with pneumonia.Methods An analytic, observational study with cross-sectional design and consecutive sampling of children aged 2 to 59 months with a clinical diagnosis of pneumonia was conducted from November 2013 to March 2014 in Dr. Hasan Sadikin General Hospital and two network hospitals. All patients underwent routine complete blood counts including MPV and measurement of serum IL-6 concentration using an enzyme-linked immunosorbent assay (ELISA) technique. Regression linear analysis was used to assess the relationship between MPV and IL-6, passive smoking, and nutritional status.Results There were 67 patients enrolled in the study. Subjects’ mean serum IL-6 concentration was 49.3 (SD 78.3) pg/mL, and mean MPV was 9.2 (SD 0.9) fL. The regression model for MPV was 7.531 + 0.662 (passive smoking) + 0.276 (weight per age) + 0.009 (IL-6).Conclusion There was a relationship between IL-6 serum concentration and MPV in children with pneumonia.
Authors and Affiliations
Melisa Lilisari, Heda Nataprawira, Dida Gurnida
Keywords
Related Articles
- EP ID EP446110
- DOI 10.14238/pi56.1.2016.57-61
- Views 69
- Downloads 0
Vitamin E effect on osmotic fragility in β thalassemia major
Background Blood transfusion remains the main therapy for anemia in β thalassemia major patients. However, frequent transfusions can cause oxidative stress in response to iron overload. Vitamin E is considered to be the...
Effect of community-based food supplementation on improving growth of underweight children under five years of age in West Nusa Tenggara
Background The prevalence of underweight children in West Nusa Tenggara is as high as 30%. This region had the third largest number of stunted children in the country. The local government has attempted to tackle this pr...
Risk factors for the failure to achieve normal albumin serum levels after albumin transfusion in neonates
Background Albumin transfusion for the treatment of neonatal hypoalbuminemia may reduce morbidity. In conditions with disrupted endothelial integrity (e.g., sepsis and critical illness), the administered albumin may leak...
Transcutaneous billirubinometry to estimate total serum bilirubin in neonatal jaundice
Background The gold standard for diagnosis of neonatal jaundice is total serum bilirubin (TSB) measurement. This method, however, is invasive, painful, and costly in terms of workload, time, and money. Moreover, repeated...
Efficacy of sputum induction from lower respiratory tract in children
Background Although sputum is a good specimen for variousexaminations, such as cytology and microbiological culture,sputum induction (SI) is not a routine procedure in children.Objective To identify the efficacy of SI to...