SOLUBILITY ENHANCEMENT OF LERCANIDIPINE HYDROCHLORIDE BY COCRYSTALLISATION.

Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 3

Abstract

In this study, the significant effect of malonic acid on enhancement of solubility of lercanidipine hydrochloride by simple solvent change process has been demonstrated. Malonic acid and lercanidipine hydrochloride were simultaneously crystallised using water as anti-solvent. The pure drug and different concentrations of malonic acid were characterized in terms of solubility, percentage yield, melting point, crystallinity, thermal behaviour, compatibility studies and surface morphology. The optimised cocrystal formulation exhibited enhancement in aqueous solubility.

Authors and Affiliations

Asija Rajesh*| Professor & Principal, Maharishi Arvind Institute of Pharmacy, Mansarover, Jaipur, Rajasthan, India-302020., Mangukia Dhruv| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Asija Sangeeta| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Patel Jaimin| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Patel Chirag J| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Patel Pinkesh| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020

Keywords

Related Articles

PREPARATION AND CHARACTERIZATION OF FAST DISNTEGRATING TABLETS OF HYDRALAZINE HYDROCHLORIDE USING DESIGN OF EXPERIMENT TECHNIQUE

Since the dose accuracy and patient’s compliance are important prerequisites for a long term treatment, there is a demand to develop a dosage form which can overcome difficulty in swallowing, inconvenience in administra...

Design and in vitro Evaluation of Mucoadhesive Mini Matrices of Losartan Potassium

Mini matrices containing Losartan potassium as a model drug were prepared by extrusion method using Hydroxy propyl methyl cellulose as matrix materials with or without xanthan gum and carbopol, and combination of xanthan...

Cervical Cancer–A Review Article

Cervical Cancer is malignant Carcinoma type of cancer originate in cervix region. The cervix is the narrow portion of the uterus where it joins with the top of the vagina. Most cervical cancers are squamous cell carcinom...

Invention of Analgesic and Anti-Inflammatory Activity of Ethanolic Extract of Mimosa Pudica Linn Leaves.

The ethanolic extract of the leaves of Mimosa pudica at the doses of 200 and 400mg/kg was tested for anti-inflammatory and analgesic activity. The extract produced dose dependent and significant inhibition of carrageen...

FREQUENCY OF DENGUE FEVER VIRUS AMONG PATIENTS WITH MALARIA-LIKE SYMPTOM IN KHARTOUM STATE.

BACK GROUND: Dengue viral infections are one of the most important mosquito borne diseases in the world. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue hemorrhagic fever (DHF),...

Download PDF file
  • EP ID EP1761
  • DOI -
  • Views 369
  • Downloads 24

How To Cite

Asija Rajesh*, Mangukia Dhruv, Asija Sangeeta, Patel Jaimin, Patel Chirag J, Patel Pinkesh (2013). SOLUBILITY ENHANCEMENT OF LERCANIDIPINE HYDROCHLORIDE BY COCRYSTALLISATION.. Journal of Biomedical and Pharmaceutical Research, 2(3), 17-25. https://europub.co.uk/articles/-A-1761