Study of Hormonal Parameters in Depressive Women
Journal Title: GJRA-Global Journal For Research Analysis - Year 2015, Vol 4, Issue 3
Abstract
The world health organization (WHO) predicts that depression would be the second greatest cause of premature death and disability by the year 2020. A gender difference in depression, with a twofold greater prevalence of depression occurring in women than in men is demonstrated. The role of reproductive hormone is found in modulating depression. This study was carried out with the aims and objectives to study 1. The levels of FSH, LH, estrogen and progesterone in depressive women. 2. The level of total cholesterol in depressive women as compared to their non-depressive counterparts Materials & Methods: This was a case control study. We included 25 women suffering from depression as cases and 25 non depressions as controls. We used DSM-IV criteria for diagnosis of depression and 17 point Hamilton rating scale for severity of depression. Estimation of FSH, LH, estrogen and progesterone was done by using ELISA test during follicular and luteal phase of menstrual cycle. Student t-test was used for statistical analysis Result: Hamilton scoring revealed mean score for group A as 20.08±4.7 (36% moderate & 46% severe depression) and group B as 2.12 ± 1.76 ( no depression). We found that the level of estradiol was significantly lower in the depressed women both in follicular phase (p<0.001) and in the luteal phase (p<0.037) while the difference in FSH, LH and progesterone was not significant in both the group. The level of cholesterol was decreased in depressive women but this reduction was not significant (p=0.07). Conclusion: There is an association with depression in women and decrease in estradiol level.
Authors and Affiliations
Dr Mohd Aslam, Dr M Hifzur Rehman, Prof. M Mobarak Hossain, Professor Abu Qamar Siddiqui
Keywords
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