Study of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as a predictor inflammatory marker for diabetic nephropathy in type 2 diabetic patients
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 7
Abstract
<strong>Background: </strong>Diabetes mellitus (DM) is a systemic disease having serious microvascular and macrovascular complications. DN in T2DM has an inflammatory pathology. Many inflammatory markers have been found to be related to DN, such as interleukin1 (IL1), IL6, IL8, transforming growth factor beta 1(TGF-β1) and tumor necrosis factor alpha (TNF α). However, their measurement is not used routinely as it is not easy to do it, in this respect. Search for inflammatory markers for the disease is a continuous process to enhance the diagnostic and treatment process. <strong>Aim of the Work: </strong>To assess neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as a predictor inflammatory markers for diabetic nephropathy in type 2 diabetic patients. <strong>Patients and Methods: </strong>This study is a prospective one that was carried out on one hundred (100) type 2 Diabetes mellitus (T2DM) patients attending to internal medicine outpatient clinic and inpatient department of internal medicine at Al-Azhar university hospital, Damietta and twenty five (25) apparently healthy volunteers as a control. The populations of the study were classified into three groups according to their level of albuminuria. All were subjected tofull history and Clinical examination, Laboratory tests include Fasting mid-stream urine samples were obtained and examined for complete urine analysis and albumin/creatinine ratio (UACR),Complete blood count (CBC), HbA1c,Fasting blood sugar, Renal Function Tests,eGFR and Abdominal ultrasonography, Fundus examination and ECG and Assessment of NLR &PLR. <strong>Results: </strong>Our study showed that there was high statistically significant increased NLR, PLR and UACR in group IB when compared to group IA, II and III. Also there was statistically significant increased NLR,PLR and UACR in group IA in comparison to group II and also there was statistically significant increased NLR,PLR and UACR in group II in comparison to group III. <strong>Conclusion: </strong>Neutrophil lymphocyte ratio (NLR) & Platelet lymphocyte ratio (PLR) was significantly associated with diabetic nephropathy (DN) and high Neutrophil lymphocyte ratio (NLR) & Platelet lymphocyte ratio (PLR) values may be considered as a predictor and a prognostic risk markers of diabetic nephropathy (DN).
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584242
- DOI 10.12816/ejhm.2018.10137
- Views 127
- Downloads 0
Hepatitis C Virus in Peripheral Mononuclear Cells in Patients on Regular Hemodialysis
Background: Occult hepatitis C virus infection (OCI) was identified as Hepatitis C virus (HCV), characterized by undetectable HCV antibodies and HCV RNA in serum, while HCV RNA is detectable in liver and peripheral blood...
Patient Compliance in Laparoscopic Cholecystectomy versus Open Cholecystectomy
Gallbladder disease is one of the most mutual procedures done worldwide. Earlier, an open technique was the regular procedure for cholecystectomy. This typically encompassed performing an intraoperative cholangiogram, an...
Incisional Hernia Repair with Abdominoplasty
<strong>Background: </strong>Abdominoplasty is considered by many general surgeons as only an aesthetic technique. It has shown to provide great benefits for patients: (1) removal of excessive skin, which promotes better...
Primary and Specialized Physicians’ Knowledge of and Attitudes Towards the Use of Complementary and Alternative Medicine in Medical Practice
<span>Background: </span><span>The use of complementary and alternative medicine (CAM) for treatment purposes in Saudi Arabia is a common practice by the public. Studies have found that using these products is not always...
Prevention of Infective Endocarditis Following Dental Practices
<strong>Introduction:</strong> Different guidelines and different regimens for prevention of infective endocarditis following operative procedures have been recommended. The purpose of this review was to explore the effe...