STUDY OF VITAMIN D LEVELS IN PULMONARY TUBERCULOSIS PATIENTS AT A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 44
Abstract
BACKGROUND Currently available literature highlights association of hypovitaminosis D with chronic diseases such as diabetes mellitus and systemic hypertension, but there are very few studies on role of vitamin D in pulmonary tuberculosis (PTB) in our population. MATERIALS AND METHODS Vitamin D levels in 180 cases of newly diagnosed active pulmonary tuberculosis (Both sputum positive and sputum negative) and 180 age and gender matched healthy controls were estimated. 25 Hydroxy vitamin D3 levels were estimated by sensitive fully automated Chemiluminescent Immunoassay (CLIA) technique. Vitamin D3 levels were categorised as sufficient, insufficient and deficient. Patients were followed for six months for final outcome (Tuberculosis cured/not cured). RESULTS Out of 180 cases, 95 (52.78%) were sputum positive and the remaining 85 (47.22%) were sputum negative. Mean vitamin D levels were significantly low in cases (12.23 ± 5.99 ng/mL) as compared to controls (18.7 ± 10.19 ng/mL) (p value <0.001). Among the 180 cases, 158 (87.78%) had vitamin D deficiency, 18 (10%) had vitamin D insufficiency; whereas among controls, 105 (58.33%) had vitamin D deficiency, 46 (25.56%) had vitamin D insufficiency. The prevalence of vitamin D deficiency and vitamin D insufficiency was higher among cases compared to controls (p-value < 0.05). CONCLUSION There is significant deficiency of Vitamin D in patients with PTB. More prospective designed studies are needed to firmly establish the direction of association between PTB and vitamin D deficiency (VDD).
Authors and Affiliations
Rohit Vasant Deshpande, Bharat Sing Rathod, Parag Nemant Rahtekar, Amol Dandurang Bhore, Swati Harish Sharma, Hitesh Lotan Mahale
Keywords
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- EP ID EP215558
- DOI 10.14260/Jemds/2017/742
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