SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL ISOXAZOLE DERIVED QUINOLINES
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 3
Abstract
A series of diversely substituted Isoxazole derived quinoline (4a-g) were obtained by the reaction of various chalcones (3a-g) with hydroxylamine hydrochloride and sodium acetate in ethanol. New compounds were characterized by FT-IR, 1H- NMR and Elemental analysis. Antibacterial and antifungal activities of those compounds were determined by disc diffusion method against A. niger, A. flavus (fungal strains), E. coli and P. aeruginosa (Gram negative bacteria), S. aureus and S. pyogenes (Gram positive bacteria) using Nystatin (for fungi) and Ciprofloxacin (for bacteria) as a standard drugs. The in vitro antifungal and antibacterial screening of the isoxazole derived quinoline (4a-g) revealed that most of the compounds in the series showed potent activity.
Authors and Affiliations
S. B. Ghodile
Keywords
Related Articles
- EP ID EP649044
- DOI -
- Views 152
- Downloads 0
CLINICAL STUDY TO EVALUATE THE EFFECTIVENESS OF JANUBASTI WITH CHINCHADI TAILA IN THE MANAGEMENT OF JANUSANDHIGATAVATA OSTEOARTHRITIS OF KNEE JOINT
Sandhigata Vata is the commonest form of articular disorder. It is a type of Vatavyadhi which mainly occurs in Vriddhavastha due to Dhatukshaya, which limits everyday activities such as walking, dressing, bathing etc. th...
CLINICAL PHARMACOKINETICS CONCEPTS IN THE DRUG DISCOVERY AND DEVELOPMENT PROCESS OF PHYTOMEDICINES IN SOME DEVELOPING COUNTRIES
Clinical Pharmacokinetics can be defined as the study of the relationship between drug dosage regimens and the concentration time profiles. There has been in the last decades a significant progress in the field of Clinic...
OJA: THE CONCEPT OF VYADHISHAMATVA (IMMUNITY) IN AYURVEDA
The concept of immunity in Ayurveda is a captivating and many faceted subjects. It is interesting to observe that the ancient Ayurvedic texts show a vivid description of the foundations of immunology thousands of years a...
ASSESSMENT OF THE LEVEL OF KNOWLEDGE REGARDING ATTENTION DEFICIT HYPERACTIVITY DISORDER AMONG SCHOOL TEACHERS
Attention deficit hyperactivity disorder (ADHD) is a medical condition characterized by difficulties with inattention, hyperactivity and impulsivity. Attention deficit hyperactivity disorder can have a profound effect on...
INSOMNIA- AN INCREASING TREND IN PRESENT ERA
Sleep is a natural phenomenon of giving adequate rest to the body and mind. Insomnia is the inability to fall asleep at night for many hours or inability to have a sound sleep, which deprives one of natural rest and inte...