Synthetic Utility of Aza Heterocyclics: A Short Review
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 3
Abstract
Azaheterocyclic compounds contain nitrogen atom in the ring. They are of vital importance in the race to improve our understanding of basic chemistry which underlies nearly all of the important life-processes and a large proportion of transformations leading to and creating the increasingly sophisticated products, which enhance our society today. A large numbers of azaheterocyclic compounds are well known and this number is increasing rapidly because they hold a special place among pharmaceutically significant natural products and synthetic compounds. The chemistry of azaheterocyclic compounds is as logical as that of aliphatic or aromatic in character, depending on their electronic constitution. Their study is of great interest both from the theoretical as well as practical standpoint. Azaheterocyclic compounds are very widely distributed in nature and are essential to life in various ways. Compounds such as alkaloids, antibiotics, essential amino acids, vitamins, haemoglobin, hormones and a large number of synthetic drugs and dyes contain azaheterocyclic ring systems. Knowledge of azaheterocyclic chemistry is useful in biosynthesis as well as in drug metabolism. There are also a large number of azaheterocyclic compounds with other important practical applications as antioxidants, vulcanization accelerators, copolymers, solvents photographic sensitizer and developers, dyestuffs and many are valuable intermediates in synthesis. Azaheterocycles are omnipresent extremely in all branches of chemistry and biochemistry as well as in our lives. Another important property of azaheterocyclic compounds is their extraordinarily participation in a wide range of reactions. Depending upon pH of the medium, they may behave as acids or bases, forming anions or cations. Some interact readily with electrophilic reagents, other with nucleophiles, yet others with both. Some are readily oxidized, but resist reduction, while others can be readily hydrogenated but are stable towards the action of oxidizing agents. The ability of many azaheterocyclic compounds to produce stable complexes with metal ions has great biochemical significance. All these results prove that azaheterocyclic compounds are excellent scaffolds for obtaining a wide variety of compounds and speeding up research activity.
Authors and Affiliations
A. P. Rajput, Anita R. Kankhare
Keywords
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