Thalassemia: Impact of consanguineous marriages on most prevalent monogenic disorders of humans

Journal Title: Asian Pacific Journal of Tropical Disease - Year 2016, Vol 6, Issue 10

Abstract

Thalassaemia is an inherited autosomal recessive disorder closely associated with consanguineous marriages. A literature search was conducted with an aim to investigate thalassemia and consanguineous marriages. Articles were searched from Google Scholar and Pubmed information regarding thalassemia associated complications, epidemiology of thalassemia and association between consanguineous marriages and thalassemia, which was subjected to contemplation. Thalassemia carrier rate varies differently in different regions of the world. In Indian subcontinent and China, Central Asia, South Europe (also known as North Mediterranean) and Arab Region, the thalassemia carrier rates were approximately 1%–40%, 4%–10%, 1%–19% and 3%, respectively. In Pakistan, the annual number of infants born with beta thalassemia is the highest as compared to other countries from Eastern Mediterranean Region. Although the management and control of thalassemia is a difficult task, it can easily be achieved via the assistance of prenatal diagnosis and prevention programs. Consanguineous marriages should be avoided to further limit the future burden of thalassaemia disease.

Authors and Affiliations

Keywords

Related Articles

Assessing parasitic infestation of vegetables in selected markets in Metro Manila, Philippines

Objective: To assess the parasitic infestation of vegetables in selected markets in Metro Manila, Philippines. Methods: A total of 80 vegetables were purchased from public and private markets in Munoz, Quezon City, and A...

The recent outbreaks of Zika virus: Mosquito control faces a further challenge

The recent outbreaks of Zika virus infection occurring in South America, Central America and the Caribbean, represent the most recent of four key arrivals of arboviruses in the Western Hemisphere over the last 20 years....

Mosquito distribution and West Nile virus infection in zoos and in important sites of migratory and resident birds, Thailand

Objective: To investigate the distribution of mosquito species in the zoos and in important sites of migratory and resident birds and evaluate West Nile virus (WNV) infection in mosquito species. Methods: Mosquitoes dist...

Mosquito larvicidal and ovicidal activity of Delonix elata (L.) Gamble against Culex quinquefasciatus Say (Diptera: Culicidae)

Objective: To determine the larvicidal and ovicidal efficacy of different solvent leaf and seed extract of Delonix elata (D. elata) against filariasis vector Culex quinquefasciatus (Cx. quinquefasciatus). Methods: Twenty...

Download PDF file
  • EP ID EP226972
  • DOI 10.1016/S2222-1808(16)61142-8
  • Views 59
  • Downloads 0

How To Cite

(2016). Thalassemia: Impact of consanguineous marriages on most prevalent monogenic disorders of humans. Asian Pacific Journal of Tropical Disease, 6(10), 837-840. https://europub.co.uk/articles/-A-226972