The Associations of Plasma Levels of Beta Amyloid, Insulin, Insulin-Degrading Enzyme and Receptor of Advanced Glycosylation End Product with Cognitive Impairment in Type 2 Diabetes Mellitus Patients
Journal Title: Turkish Journal of Immunology - Year 2017, Vol 5, Issue 2
Abstract
Background: Diabetes mellitus patients are at a higher risk of developing cognitive impairment compared to the non-diabetes mellitus population. There are various mechanisms underlying the association between diabetes mellitus and impaired cognitive function, including the failure of glucose metabolism, insulin resistance, and increased formation of amyloid beta, insulin-degrading enzyme (IDE) and receptor of advanced glycosylation end product (RAGE). Objective: This study aimed to find the association of the levels of beta amyloid, insulin, IDE, and RAGE with the onset of cognitive impairment in diabetes mellitus patients. Methods: A case control study was conducted on 60 patients classified as 30 subjects with cognitive impairment and 30 subjects without cognitive impairment. Cognitive function was examined using the Montreal Cognitive Assessment Indonesian version (MoCA-Ina) which is a neuropsychological test. The plasma levels of beta amyloid, insulin, IDE and RAGE were measured by Elisa technique. Mean differences in the levels of biomarkers in both groups were analyzed using the Mann-Whitney U test and the association between two variables was analyzed using the chi-square test. Results: It was found that the plasma levels of insulin and beta amyloid 42 were lower in the group with cognitive impairment and there was an association between low plasma levels of insulin and beta amyloid 42 with the occurrence of cognitive impairment (p<0.05) Conclusion: There seems to be a correlation between plasma insulin level, beta amiloid and cognitive impairment in patients with diabetes mellitus.. Keywords: Biomarkers, cognitive disorders, diabetes mellitus
Authors and Affiliations
Yuliarni Syafrita, Darwin Amir, Eva Decroli
Keywords
Related Articles
- EP ID EP449855
- DOI 10.25002/tji.2017.550
- Views 102
- Downloads 0
Effect of Monoclonal Antibody to Human Zona Pellucida 3 in Luteineizing Hormone Receptor Expression, Estradiol Levels and de Graaf Follicles Quantity in Mice
Objective: This research aimed to evaluate effect of monoclonal antibody to human Zona Pellucida 3 (Mab-hZP3) on luteineizing hormone (LH) receptor expression, estradiol levels and de Graaf follicles quantity of mus musc...
The Association Between Vitamin D Levels and Infections in Patients with Primary Immunodeficiency
ntroduction: Vitamin D is a hormone responsible in the regulation of immune response. This study was designed to assess the relationship of vitamin D deficiency on the development of infections in patients with primary i...
Interleukin-2 Immunotherapy for Advanced Cancer
Interleukin-2 (IL-2) was the first approved immunotherapy to show efficacy in advanced cancer. 13–20% of patients with metastatic renal cell carcinoma and metastatic melanoma receiving high-dose IL-2 treatment showed obj...
The Effect of Viral Infections and Allergic Inflammation in Asthmatic Patients on Immunotherapy
Introduction: The prevalence of allergic asthma are increasing, and the clinical outcome and risk factors of immunotherapy in the treatment of allergy have not been well established. Especially, the impact of viral infec...
Stem Cells and Regenerative Medicine
Stem cells are self-renewing, non-differentiated cells that can be transforming into many different cell types and can form all the tissues and organs in our body when proper conditions are provided. Stem cells can be di...