The effectiveness of diosmectite in the treatment of irritable bowel syndrome with diarrhea

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The effectiveness of diosmectite in the treatment of irritable bowel syndrome with diarrhea

Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 5

Abstract

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, characterized by abdominal pain, bloating, changes in the frequency and consistency of stool. These symptoms cannot be explained by structural changes in the intestines. To date, there is no special laboratory test or specific biomarker for the diagnosis of IBS. Thus, IBS is classified as a functional disorder. The diagnosis is established on the basis of characteristic complaints, medical history, a thorough physical examination and additional studies, taking into account the absence of symptoms of an organic disease. Although a large number of studies have been conducted in this area, the pathophysiology of IBS is complex and not fully understood. Multiple factors are believed to contribute to the development of symptoms in patients with IBS. Altered gastrointestinal motility, visceral hypersensitivity, and the interaction between the brain and intestines are important classic concepts in IBS pathophysiology. New studies in this area include mild post-infection inflammation, genetic and immunological factors, altered microbiota, dietary factors, and enteroendocrine cells. Despite significant successes in understanding the pathogenesis of IBS with diarrhea, the treatment of this category of patients presents great difficulties. Few treatments have shown efficacy and safety in IBS with a predominance of diarrhea. The use of diosmectite is proposed as an effective and safe treatment for IBS with diarrhea. Smectalia — a new dosage form of smectite dioctahedral registered in the pharmaceutical market of Ukraine. Due to the spatial structure and its properties, diosmectite protects the intestinal mucosa, helps to reduce diarrhea, flatulence, abdominal pain. The use of diosmectite in patients with IBS with a predominance of diarrhea has shown good efficacy and a high safety profile. The results of the analyzed clinical studies provide the basis for the widespread use of diosmectite in treatment regimens for IBS with diarrhea.

Authors and Affiliations

G. D. Fadieienko, T. A. Solomentseva

Keywords

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EP ID EP675477
DOI 10.30978/MG-2019-5-59
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