The multiple functions of pluripotent cells: can Embryoid Bodies be a screening tool for environmental toxicity?
Journal Title: Biomedicine & Prevention - Year 2016, Vol 2016, Issue 1
Abstract
After the development of embryonic stem cell lines and the possibility of mimicking in vitro embryo differentiation through the formation of embryo-like structures called embryoid bodies, great effort has been put to exploit this new in vitro systems to develop tools for screening different compounds for their embryotoxic and/or teratogenic potential. In this respect, the Embryonic Stem cell Test has been developed. In the present mini review we give a brief overview of the literature demonstrating the predictivity of the Embryonic Stem cell Test and the possibility to use the test to screen xenobiotics, including environmental pollutants.
Authors and Affiliations
Luisa Campagnolo, Micol Massimiani, Giuseppina Somma, Andrea Magrini, Antonio Pietroiusti
Keywords
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- EP ID EP334746
- DOI 10.19252/000000037
- Views 170
- Downloads 0
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