The role of immunotherapy in eliminating high-risk treatments for pediatric cancer
Journal Title: Journal of Current Biomedical Reports - Year 2021, Vol 2, Issue 2
Abstract
Chemotherapy, radiation, and surgery are often ineffective in treating refractory or chronic tumors in children. Recent advances in cancer immunotherapy have also improved the outcome of many human tumors, resulting in significant responses in patients who have previously refused to respond to other treatments. The immune system is made up of cells and proteins that work together to maintain immunity against pathogens. Cancer cells can adapt and metastasize over time, express different neoantigens, or express more immune-suppressing mechanisms, allowing them to be identified and eradicated. In this study, we focus on immunotherapy for pediatric cancer and its progression using natural killer (NK) cells, chimeric antigen receptor T cells (CAR-T), and oncolytic virus cells in these patients. For all intents and purposes, toxicity is a concern. Although immunotherapy is believed to have fewer long-term side effects than chemotherapy and radiation therapy, they may have a high rate of short-term side effects, depending on the cause and purpose. These complications can lead to life-threatening illnesses, from mild illnesses such as fever and headaches to more severe illnesses such as autoimmune, neurotoxicity, and opportunistic infections. Any of the problems listed, for example, cytokine release syndrome, can be fatal. Different intensities require multiple tests and trials.
Authors and Affiliations
Zahra Farhoud, Sepehr Bozorgchenani
Keywords
Related Articles
- EP ID EP695484
- DOI -
- Views 122
- Downloads 0
Bacterial etiology and antibiotic susceptibility pattern of female patients with urinary tract infection referred to Imam Khomeini Hospital, Ahvaz, Iran, 2019
Urinary tract infection (UTI) is one of the most frequent infections among women, and if untreated could lead to severe complications. The treatment of UTI is difficult due to the appearance of pathogens with increasing...
Current applications of the microbiome engineering and its future: A brief review
In the human body there are many microorganisms with a variable genetic content. These microorganisms play an important role in the metabolism, homeostasis, immune system and generally human health. Over the millions of...
The sound of getting rid of coronavirus by RNA interference technology: RNAi against COVID-19
No Abstract.
Evaluation the intestinal level of LCN2/NGAL in patients with Clostridium difficile infection in the south of Iran
Clostridium difficile is a Gram-positive obligate anaerobic bacterium that recognized an important pathogen of humans. The present study aimed to evaluate the intestinal level of neutrophil gelatinase-associated lipocali...
Detection of carbapenem resistance and virulence genes among Acinetobacter baumannii isolated from hospital environments in center of Iran
Carbapenem-resistant Acinetobacter baumannii are the top urgent antibiotic resistance threat in the world. The aims of this study were the determination of carbapenem-resistant genes and virulence genes among isolates fr...