TO STUDY THE EFFECT OF THE PARENTERAL ADMINISTRATION OF CIMETIDINE ON SERUM PROLACTIN LEVEL IN EXPERIMENTAL ANIMALS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 13
BACKGROUND Among the H2 receptor antagonists, Cimetidine promotes healing of peptic ulcer and reduces ulcer pain, but produces a few significant side effects- gynaecomastia, galactorrhoea, etc. H1 antagonists and H2 agonists suppress prolactin release in suckled mother, while H1 agonists and H2 antagonists release prolactin in non-suckled mother.2 The relationship between H2 receptor inhibitory and H1 receptor stimulant for the raise or decrease of serum prolactin level and also for involvement of third ventricle in hypothalamus area is to be investigated. MATERIALS AND METHODS The present study was to ascertain the site of action of Cimetidine for the raised serum prolactin, whether peripheral action or central action. Therefore, the route of administration of the H2 receptor antagonist Cimetidine was chosen as intravenous and intracerebroventricular respectively. Finally, serum prolactin level was estimated by drawing blood from the ear vein of the experimental animal (Rabbit) every 15 mins, 30 mins and 45 mins respectively. Then, serum prolactin levels were compared and analysed statistically. RESULTS The serum prolactin level was found significantly raised at 15 mins (p < 0.05) and 30 mins (p < 0.001) after the IV Cimetidine. However, there is no significant difference between IV Cimetidine and ICV Cimetidine pre-treated group as Diphenhydramine blocked H1 receptor. CONCLUSION So, it can be concluded that Cimetidine causes raise in serum prolactin level due to its peripheral and central action.
Authors and Affiliations
Oinam Joychandra Singh, S. Losica R. K
MRI STANDARD TECHNICAL PROTOCOL VERSUS ADVANCED HEPATOBILIARY PROTOCOL IN DIAGNOSING SOLITARY CYSTIC HEPATIC LESIONS
BACKGROUND Solitary cystic liver lesions are not uncommon, comes with varying age groups. To decide surgical approach and treatment planning of cystic mass lesion, specific diagnosis with high sensitivity and specificity...
PROSPECTIVE CLINICAL STUDY ABOUT THE PROGNOSIS IN EXTRAHEPATIC BILIARY ATRESIA PATIENTS FOLLOWING KASAI’S PORTOENTEROSTOMY
PURPOSE To evaluate the prognosis in extrahepatic biliary atresia patients following Kasai’s portoenterostomy. MATERIALS AND METHODS This prospective study of 64 Extrahepatic Biliary Atresia cases was conducted...
A STUDY ON INTRAOPERATIVE AWARENESS AND RECALL DURING GENERAL ANAESTHESIA- A PROSPECTIVE OBSERVATIONAL STUDY
BACKGROUND Intraoperative awareness occurs when a patient becomes conscious during a surgical procedure performed under general anaesthesia and subsequently has recall of these events. The experience can be quite disturb...
[b]BACKGROUND:[/b] Menstruation has often been dealt with secrecy in many cultures. Such perceptions coupled with poor and inadequate sanitary facilities have often kept girls from not attending schools especia...
PRESENTATION OF CASE Odontogenic Keratocyst or as now better called as Keratocystic Odontogenic Tumour is a type of cyst with locally aggressive behaviour with high recurrence rate and typical histological appearance and...
How To Cite
Oinam Joychandra Singh, S. Losica R. K (2018). TO STUDY THE EFFECT OF THE PARENTERAL ADMINISTRATION OF CIMETIDINE ON SERUM PROLACTIN LEVEL IN EXPERIMENTAL ANIMALS. Journal of Evolution of Medical and Dental Sciences, 7(13), 1599-1601. https://europub.co.uk/articles/-A-412174