Toxicological characteristics of diisodecyl phthalate Plasticiser
Journal Title: Український журнал сучасних проблем токсикології - Year 2018, Vol 81, Issue 1
Abstract
Objective. Analysis and generalisation of literature data and own studies on the toxicological characteristics of diisodecyl phthalate, plasticiser — high molecular weight phthalate. Materials and methods. Study of toxicity parameters of diisodecylphthalate, plasticiser. The analytical review of scientific publications has been made using the abstract database of scientific libraries and text database of PubMed publications. Results. The paper provides a scientific analysis of literature and own studies on the parameters of acute, subchronic, chronic toxicity, and long-term effects of diisodecyl phthalate with various routes of entry into the body of experimental animals. Conclusions. Diisodecyl phthalate is characterised by low values in terms of acute toxicity on the body of experimental animals. Longterm administration of diisodecyl phthalate is associated with hepatotoxic effects. Embryotoxic and teratogenic effects are manifested in high concentrations, which is not a limiting criterion in the systematic assessment of the plasticiser safety. Mutagenic and carcinogenic effects have not been established.
Authors and Affiliations
А. V. Kharlamova, V. F. Bogoyavlenska, O. G. Bychova
Keywords
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