X-ray Crystal Structure of COX-2 Enzyme as a Tool to Predict Active Sites of Bitter Taste Receptors
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 12, Issue 5
Abstract
This commentary discusses a novel approach to be used in the design of active sites of bitter taste receptors, especially TAS2R14, by using the X-ray crystal structure of the enzyme COX-2 and chemical structures of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) that bind effectively to COX enzymes and activate the bitter taste receptor TAS2R14. The suggested approach consists of docking calculations of the NSAIDs (ligands) to the active site of COX-2 and utilizing the data obtained in better understanding the nature of the interactions between bitter tastants and the chemical groups within the active site of TAS2R14 receptor.
Authors and Affiliations
Rafik Karaman, Gennaro Mecca, Salma Jumaa
Keywords
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- EP ID EP342067
- DOI 10.9734/BJPR/2016/28169
- Views 103
- Downloads 0
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