Modern Pediatrics. Ukraine

Modern Pediatrics. Ukraine

Basic info

  • Publisher: Group of Companies Med Expert, LLC,
  • Society/Institution: Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  • Country of publisher: ukraine
  • Date added to EuroPub: 2019/Sep/28

Subject and more

  • LCC Subject Category: Pediatrics
  • Publisher's keywords: Pediatrics; children; neonatalogy; pretern infants; bronchial asthma; inflammatory diseases
  • Language of fulltext: ukrainian, russian, english
  • Time from submission to publication: 5 weeks

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? Yes

Open access & licensing

  • Type of License: CC BY-NC
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2016
  • Does the author retain unrestricted copyright? True
  • Does the author retain publishing rights? True

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Vernadsky National Library of Ukraine
  • Deposit policy registered in: None

This journal has '1' articles

The features of clinical and electroencephalographic diagnosis of seizures in preterm infants

The features of clinical and electroencephalographic diagnosis of seizures in preterm infants

Authors: Dariia Kostiukova https://orcid.org/0000-0002-8648-1225 National Children's Specialized Hospital OKHMATDYT, Kyiv, Ukraine Shupyk National Medical A...
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Abstract

Neonatal seizures are the most common emergency paroxysmal conditions in patients of the neonatal intensive care units. The aim of the study: to determine clinical and electroencephalographic signs of seizures in preterm infants with paroxysmal conditions, taking into account gestational age at birth and post-menstrual age in the dynamics of treatment. Materials and methods. Complex clinical and neurophysiological examination of 90 premature babies was conducted (group I – 29 children with gestational age 24–28 weeks, group II — 45 children with gestational age 29–32 weeks, group III — 16 children with gestation age 33–36 weeks). Results. Preterm infants of the study groups had manifestations of combined perinatal pathology, among which the incidence of perinatal CNS lesions was 24.1% in group I, 33.3% in group II and 37.5% in group III. According to neuromonitoring data, electrographic (31%, 42% and 43.6%, p>0.05), clonic (24.1%, 20% and 25%, p>0.05) and sequential (10.3%), seizures predominate (9%, 12.5%, p>0.05). Dynamics of clinical and electroencephalographic examination of preterm infants according to the increase postmenstrual age showed a gradual decrease in the frequency of electroclinic seizures (in group I — from 89.7% to 3.4%, p<0.0001; in group II — from 60% to 7%, p<0.0001; in group III — from 75% to 6.3%, p=0.0001) and an increase in the frequency of electrographic seizures (from 6.9% to 44.9%, p=0.0011; from 15,6% up to 27%, p>0.05; from 6.3% to 44%, p>0.05). At the corrected age of 1.5–3 months postpartum, convulsions persisted only in 24.1% of cases of group I, in 15.5% of cases of group II and in 25% of group III, p>0.05) with the prevalence of electrographic seizures. Dynamic comprehensive neuromonitoring allowed for timely adjustment of anticonvulsant therapy, which increased the proportion of children without convulsions. Conclusions. High frequency of seizures, as one of the main manifestations of paroxysmal conditions, preterm infants and long-term preservation of electrographic seizures during the first months of postpartum life determine the need for complex neuromonitoring with the inclusion of standard electroencephalography during the first 3 months of corrected age and objective age diagnosis, correction of therapeutic complex. The children were examined after obtaining the written consent of the parents, following the basic ethical principles of scientific medical research and approval of the research program by the Commission on Biomedical Ethics of the Shupyk National Medical Academy of Postgraduate Education. No conflict of interest was declared by the authors.

Keywords: preterm infants; neonatal seizures; standard electroencephalography

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