Indian Journal of Pharmaceutical and Biological Research

Indian Journal of Pharmaceutical and Biological Research

Basic info

  • Publisher: Editorial office of Indian Journal of Pharmaceutical and Biological Research (IJPBR)
  • Country of publisher: india
  • Date added to EuroPub: 2017/May/17

Subject and more

  • LCC Subject Category: Biological Sciences, Pharmacology
  • Publisher's keywords: Biological Science
  • Language of fulltext: english
  • Time from submission to publication: 8 weeks

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Open access & licensing

  • Type of License: Other
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2013
  • Does the author retain unrestricted copyright? True
  • Does the author retain publishing rights? True

Best practice polices

  • Permanent article identifier: None
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '225' articles

Status of Herbal Drugs in Cardiovascular Research: A Review

Status of Herbal Drugs in Cardiovascular Research: A Review

Authors: Ravinderpal Kaur| Pharmacology and Toxicology Research Lab, Department of Pharmacology ASBASJSM College of Pharmacy, Bela (Ropar)-140111. Punjab (Indi...
(25 downloads)
Abstract

Globally, cardiovascular diseases (CVD) constitute a leading cause of mortality. Heart disease in India occurs 10 to 15 years earlier than in the west. One fifth of the deaths in India are from coronary heart disease (CHD). The global burden of disease due to cardiovascular diseases (CVDs) is escalating, principally due to a sharp rise in the developing countries which are experiencing rapid health transition. More than 2000 plants have been listed in the Traditional (Herbal/Alternative) systems of medicine and some of these are providing comprehensive relief to the people suffering from cardiovascular diseases, specially “hyperlipidemia” and “ischemic heart disease”. WHO reports indicate that around eighty percent of the global population still relies on botanical drugs and several herbal medicines have advanced to clinical use in modern times. This review work explains chemical and pharmacological status of various cardioprotective plants including phytoconstituents responsible for cardioprotection, pharmacological screening model and mechanism involved in cardioprotection.

Keywords: Cardiovascular diseases, antioxidant, cardioprotective, phytoconstituents
Berberis lycium a Medicinal Plant with Immense Value

Berberis lycium a Medicinal Plant with Immense Value

Authors: Purvika Sood| Department of Food Science and Nutrition, CSK Himachal Pradesh Krishi Vishv Vidyalya, Palampur- 176062, India, Rajni Modgil| Department...
(24 downloads)
Abstract

Berberis lycium belong to family Berberidaceae is an evergreen shrub growing in Himalayan region. The various parts of the plant like root, bark, stem, leaves and fruits are used by the people as a medicine or food. This plant has also gained wide acceptance for its medicinal value in ayurvedic drugs. The plant is known to prevent liver disorders, abdominal disorders, skin diseases, cough, ophthalmic etc. Moreover the pharmacological studies have shown that plant is hypoglycemic, hyperlipidemic, hepatoprotective, anticarcinogenic and antipyretic properties. The fruits of the plant are also very nutritious and are rich source of vitamins, minerals, antioxidants, anthocyanin etc. These fruits are consumed in raw form or are utilized in the preparation of juices, jams, preserve etc. by the local inhabitants. In the present article an attempt has been made to summarize the various properties of Berberis lycium plant.

Keywords: Berberis lycium, kasmal, wild plants, medicinal plant
In vitro antimicrobial activity of leaves and bark extracts of Ficus religiosa (Linn.)

In vitro antimicrobial activity of leaves and bark extracts of Ficus religiosa (Linn.)

Authors: G. Ramakrishnaiah| Department of Biotechnology Sree Vidyanikethan Engineering College, A. Rangampet, Tirupati- 517102, Andhra Pradesh, India., T. Hari...
(24 downloads)
Abstract

In the present study we investigated antimicrobial activity of diethyl ether and methanol extractions of bark and leaves of Ficus religiosa plant against three bacteria (E.coli, Staphylococcus aureus & Pseudomonas aurignosa) and one fungi (Aspergillus niger). The results showed that the methanol extracts of both leaves and bark showed antimicrobial activity on three tested bacteria and no effect on A.niger. In methanol extracts S.aureus showed maximum sensitivity (inhibition zone 28mm) followed by E.coli (inhibition zone 16mm) and Pseudomonas aeruginosa (inhibition zone 12mm). Diethyl ether extracts of leaves were also showed maximum inhibition on S.aureus followed by E.coli and P.aeruginosa. Both methanol and diethyl ether extracts of bark showed antimicrobial activity on three types of tested bacteria and very less inhibition activity on A.niger. But comparatively bark extracts of both the solvents were showed less antimicrobial activity than leaves extracts on the tested microbes.

Keywords: Antimicrobial activity, bacteria, Ficus religiosa
Formulation and Characterization of Transdermal Patches of Losartan

Formulation and Characterization of Transdermal Patches of Losartan

Authors: Ujjawal Nautiyal| Department of Pharmacy, Siddartha Institute of Pharmacy, Dehradun, U.K, (India), Devendra Singh| Cipla Limited, Paonta Sahib, Sirmou...
(24 downloads)
Abstract

Administration of drugs through skin has received great attention through the last decade. Hence this study aims to formulate an anti-hypertensive drug losartan as transdermal patch using different bioadhesive polymers such as ethyl cellulose, cellulose acetate, and polyvinyl pyrrolidon,hydroxyl propylemethylcellulose with plasticizers propylene glycol (PG). Patches were prepared though solvent evaporation method, The backing membrane was a non permeable aluminium foil laminated with polyethylene and evaluated for thickness uniformity, Uniformity of weight, Scanning Electron Microscopy, Surface pH, Swelling studies, Drug content uniformity Effect on agingn, skin irritation potential, and In vitro release study.Patches exhibited controlled release over more than 2 hr.It was concluded that patches containing 30 mg of losartane with HPMC (formulation F2) ,showed moderate swelling, surface pH and controlled drug release, thus can be selected for the development of transdermal patches for effective uses.

Keywords: Cardiovascular diseases, antioxidant, cardioprotective, phytoconstituents
Comparaative study of Lipid profile and level of Antioxidant enzymes in cigarette smokers with non cigaretee smokers

Comparaative study of Lipid profile and level of Antioxidant enzymes in cigarette smokers with non cigaretee smokers

Authors: P. K. Chauhan| School of Bioengineering and Food Technology, Shoolini University, Solan, H.P. India, Rishma| Department of Biotechnology, Himachal Ins...
(23 downloads)
Abstract

Cigarette smoking is the serious health problems and most important avoidable cause of death in world. Worldwide more than 8 million people currently die each year from smoking half of them before of the age of 60. Every cigarette reduces the life span by about 5 minutes. Smoke contains oxidising agents and the oxidation reactions can produce free radicals. In turn, these radicals can start chain reactions that damage cells. In the present study 40 male subjects were divided into four different groups and their lipid profile have been estimated by various tests i.e. Cholesterol, Triglyceride, HDL-C, LDLC, VLDL-C. It was observed that in cigarette smokers HDL-C level decreased and cholesterol, triglyceride, LDL-C, VLDL-C level increased as compared to the control i.e. non- cigarette smokers. In case of MDA and Antioxidant enzymes test, the value of MDA increases and antioxidant enzymes decreases in cigarette smokers as compared to the control i.e. non- cigarette smokers. The variation in the level of lipid profile and antioxidant enzymes from normal values causes several diseases such as Lung cancer, other cancers, heart disease, and stroke and has numerous immediate health effects on the brain and on the respiratory, cardiovascular, gastrointestinal, immune systems.

Keywords: Oxidising agents, HDL- cholesterol, MDA, Triglycerides
Evaluation of Physiochemical Screening and Standardization on the Root of Rotula aquatica Lour

Evaluation of Physiochemical Screening and Standardization on the Root of Rotula aquatica Lour

Authors: Abhishek B| Department of Pharmacognosy, Himachal Institute of Pharmacy, Paonta Sahib, H.P. India, Avinash Saini| Department of Pharmacognosy, Himacha...
(26 downloads)
Abstract

The root of Rotula aquatica is also called as pashanbed, belonging to the family Borogenaceae. It is widely distributed in India from kumaun to Assam and western to southern India.The medicinal values of plant lie in their component phytochemicals such as alkaloids, flavonoids, phenolic compounds and other nutrients like as amino acid, proteins, which produce a definite physiological action on the human body. The proximate values such as moisture content, ash value, extractive value, were carried out. The dried roots powder was subjected to successive extraction with different solvents like petroleum ether, benzene, chloroform, methanol, ethanol and water. Macroscopic as well as microscopic studies of any crude drug are the primary steps to establish its botanical quality control before going to other studies. Hence Standardization of crude drug plays a very important role in identifying the purity and quality of crude drugs. The present investigation reveals Standardization which include Moisture Content, Total ash, Acid insoluble ash, Water soluble ash, Water soluble Extractive value, Alcohol soluble Extractive value, Phytochemical screening, and further isolation and identification of Phytoconstituents.

Keywords: Rotula aquatica, phytochemicals, crude drug
Formulation and Dissolution Study of Valsartan Immediate Release Tablets

Formulation and Dissolution Study of Valsartan Immediate Release Tablets

Authors: B. Brahmaiah| Department of Pharmaceutics, Priyadarshini Institute of Pharmaceutical Education & Research (PIPER), 5th Mile, Pulladigunta, Kornepadu (...
(23 downloads)
Abstract

In the present study, design of oral immediate release tablets of Valsartan by direct compression technique was carried out. The main aim and objective of the work is to formulate immediate release tablets using different direct compression vehicles (DCV’S) in different ratios. The main motive is to compare the dissolution profile of these formulations and conclude the best formulation which release drug at a faster rate. To determine the best fit dissolution profile for the dosage forms. Valsartan tablets were formulated by using microcrystalline cellulose (diluents), potato starch, acacia (binder) and magnesium stearate (lubricant). The granules were compressed into tablets and were subjected to dissolution studies. The dissolution profile of the formulation F2 was found to have better dissolution rate compared to others. The In-vitro dissolution studies of all the formulations were conducted and the results were obtained, it was concluded that formulation F2 was the best with fast release of drug compared to others.

Keywords: Valsartan, Acacia; MCC, Lactose; Sucrose, Fructose, direct compression vehicles (DCV’S)
Flavonoid Contents From Some Capparidaceous Medicinal Plants of North-West Rajasthan

Flavonoid Contents From Some Capparidaceous Medicinal Plants of North-West Rajasthan

Authors: B.B.S. Kapoor| Herbal Research laboratory, P.G. Department of Botany, Dungar College, Bikaner, India, Raksha Mishra| Herbal Research laboratory, P.G....
(23 downloads)
Abstract

Evaluation of flavonoid contents from three selected medicinal plant species of capparidaceae family growing in North–Western Rajasthan was carried out. The leaves of Capparis decidua, Cleome gynandra and Cleome viscosa were analysed for flavonoid contents i.e. Quercetin and Kaempferol. Flavonoid contents like Quercetin and Kaempferol were isolated and identified. The maximum total flavonoid contents (1.16mg./gdw) was found in leaves of Capparis decidua while minimum (0.71mg./gdw) in leaves of Cleome viscosa

Keywords: Flavonoid contents, Capparidaceous medicinal plants, North-west Rajasthan
Cyclic Changes In The Hypothalamo Neurohypophysial System of Xenentodon Cancila (HAM.)

Cyclic Changes In The Hypothalamo Neurohypophysial System of Xenentodon Cancila (HAM.)

Authors: Z B Khuroo| Department of Zoology, Govt. College Baramulla, Kashmir (J&K), India
(31 downloads)
Abstract

The presence of functional hypothalamo-hypophysial neurosecretory system in vertebrates has led to revise earlier views regarding the hypothalamus-pituitary relationship. The hypothalamo-neurohypophysial system which consists of hypothalamic nuclei, their axonal fibres forming tractus preoptico-hypophyses and the neurohypophysis) works as a morphological as well as a physiological connection between the hypothalamus and the pituitary gland. In fishes, fibres from the neurosecretory hypothalamic nuclei terminate in the neurohypophysis, which remains inter digitized with the adenohypophysis and provides a very close association between the neurosecretory fibres and pars intermedia of the pituitary gland forming a neuro-intermediate lobe. Hypothalamo-Neurosecretory complex of Xenentodon cancila consists of Nucleus Pre-opticus (NPO), Nucleus Lateralis Tuberis (NLT) and their axonal tracts. NPO is a paired structure situated on either side of the third ventricle anterodorsal to the optic chiasma. NPO is divisible into a dorsal Pars Magnocellularis (PMC) consisting of large neurosecretory cells and Pars Parvocellularis (PPC) formed of smaller neurons. Neurons of PMC and PPC contribute beaded axons to form neurohypophysial tract. Herring bodies are seen in the anterior as well as posterior neurohypophysis

Keywords: Hypothalamo-neurosecretory complex, tractus preoptico hypophyseus, Xenentodon cancila
Antimicrobial Screening of Some capparidaceous Medicinal Plants of North-West Rajasthan

Antimicrobial Screening of Some capparidaceous Medicinal Plants of North-West Rajasthan

Authors: B.B.S. Kapoor| Herbal Research laboratory, P.G. Department of Botany, Dungar College, Bikaner, India, Raksha Mishra| Herbal Research laboratory, P.G....
(21 downloads)
Abstract

Antimicrobial screening of ethyl ether and alcoholic extracts of leaves of three selected medicinal plant species of capparidaceae family growing in North–Western Rajasthan was carried out. Capparis decidua, Cleome gynandra and Cleome viscosa showed positive reactions against bacterial pathogens i.e. Staphylococcus aureus, Escherichia coli and a fungal pathogen Candida albicans

Keywords: Antimicrobial screening, Capparidaceous medicinal plants, North-west Rajasthan
Antimicrobial Screening of Some capparidaceous Medicinal Plants of North-West Rajasthan

Antimicrobial Screening of Some capparidaceous Medicinal Plants of North-West Rajasthan

Authors: B.B.S. Kapoor| Herbal Research laboratory, P.G. Department of Botany, Dungar College, Bikaner, India, Raksha Mishra| Herbal Research laboratory, P.G....
(24 downloads)
Abstract

Antimicrobial screening of ethyl ether and alcoholic extracts of leaves of three selected medicinal plant species of capparidaceae family growing in North–Western Rajasthan was carried out. Capparis decidua, Cleome gynandra and Cleome viscosa showed positive reactions against bacterial pathogens i.e. Staphylococcus aureus, Escherichia coli and a fungal pathogen Candida albicans

Keywords: Antimicrobial screening, Capparidaceous medicinal plants, North-west Rajasthan
Proximate Composition And Phytochemical Constituents Of Aspilia africana (Pers) C. D. Adams & Tithonia diversifolia (Hemsl) A. Gray Stems (Asteraceae)

Proximate Composition And Phytochemical Constituents Of Aspilia africana (Pers) C. D. Adams & Tithonia diversifolia (Hemsl) A. Gray Stems (Asteraceae)

Authors: Uduak Essiett| Department of Botany and Ecological Studies, Faculty of Science, University of Uyo, P.M.B. 1017, Uyo. Akwa Ibom. Nigeria., Emana Akpan|...
(25 downloads)
Abstract

Proximate composition and phytochemical constituents of stems of A. africana and T. diversifolia (Asteraceae) were investigated. The stems of these species contain anti-oxidant, anticancer, anti-tumor, anti-viral, anti-inflammatory and anti-allergic properties which cures malaria, skin diseases, athlete’s foot, asthma, gonorrhoea and to stop bleeding. The stems of these two species revealed the presence of flavonoids, tannins, saponins and cardiac glycosides. The proximate analysis of the stems of A. africana and T. diversifolia showed the moisture content of 15.7% and 20.6%, total ash of 6.10% and 6.55%, acid insoluble ash of 0.55% and 0.33%, sulphated ash of 18.8% and 14.0%, protein content of 7.87% and 9.62%, fat of 3.68% and 4.21%, fibre of 12.30% and 15.82%, carbohydrate of 75.97% and 70.35%, volatile ether soluble of 7.33% and 1.66%, water soluble of 3.33% and 0.33% and diluted alcohol soluble of 5.33% and 5.66%. The results of this study suggest the popular use of A. africana and T. diversifolia in herbal medicine.

Keywords: Aspilia Africana, Tithonia diversifolia, Phytochemical, stem, Asteraceae
Antidiabetic Effect of Pleurotus ostreatus (Jacq.ex Fr) kumm. Mushroom on Alloxan-induced Diabetic Rats.

Antidiabetic Effect of Pleurotus ostreatus (Jacq.ex Fr) kumm. Mushroom on Alloxan-induced Diabetic Rats.

Authors: Imoh Johnny| Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, P.M.B. 1017 Uyo, Akwa Ibom State-Nigeria, Josep...
(25 downloads)
Abstract

Antidiabetic effects of ethanolic extract of Pleurotus ostreatus (mushroom) on alloxan-induced diabetic rats was studied. The median lethal dose (LD50) of the extract was determined to be 3,472.14 mgkg-1 and a single dose of 380.0, 760.0 and 1140.0 body weight of the extract were intraperitoneally administered as the treatment dose and the blood glucose levels (BGL) examined for 7 hours and 15 hours (prolonged) at 2 and 4 hours intervals respectively. The extract exhibited significant (p<0.05 and p<0.01) reduction in the blood glucose levels of the albino rats. The extract compared favourably with the standard reference drug (metformin) which all gave their maximum BGL reduction at 5 hours duration. The confirmation of antidiabetic potentials of the Pleurotus ostreatus tuber has been justified in this study as claimed by traditional medicine practitionersin Akwa Ibom State.

Keywords: Pleurotus ostreatus, hypoglycaemic activity, ethanolic extract, metformin, diabetic rats
Capparidaceous Medicinal Plants of North-West Rajasthan: Good Sources of Ascorbic Acid

Capparidaceous Medicinal Plants of North-West Rajasthan: Good Sources of Ascorbic Acid

Authors: B.B.S. Kapoor| Herbal Research laboratory, P.G. Department of Botany, Dungar College, Bikaner, India, Raksha Mishra| Herbal Research laboratory, P.G....
(22 downloads)
Abstract

Ascorbic acid contents of roots, shoots and fruits of three selected medicinal plants like Capparis decidua, Cleome gynandra and Cleome viscosa of family Capparidaceae have been analysed. Maximum ascorbic acid contents were found in the fruits of Capparis decidua (108.12mg/100g.d.w.) while, minimum in the roots of Cleome viscosa (62.25mg/100g.d.w).

Keywords: Ascorbic acid contents, Capparidaceous medicinal plants, North-west Rajasthan
Studies on Some Pedological Indices, Nutrient Flux Pattern and Plant Distribution in Metropolitan Dumpsites in Uyo, Akwa Ibom State

Studies on Some Pedological Indices, Nutrient Flux Pattern and Plant Distribution in Metropolitan Dumpsites in Uyo, Akwa Ibom State

Authors: Felix Ogbemudia| Department of Botany and Ecological Studies, Faculty of Science, University of Uyo, P.M.B. 1017 Uyo, Akwa Ibom State-Nigeria, Emem Mb...
(24 downloads)
Abstract

The physical and chemical properties of soils and plants distribution in metropolitan dumpsites in Uyo, Nigeria were studied. Soil samples were collected from two popular dumpsites and analysed using standard scientific procedures. The Results showed that there were slight desparities in the nutrient profile of these dumpsites. Generally, the nutrients levels were high and soil heavy metals concentration were found to be within permissible limits. This study also revealed the monospecific nature of dumpsite 1 and higher species presence corresponding with increased nutrient levels in dumpsite site 2. This study encourages the use of dumpsites soils for agricultural purpose(s) when the soil heavy metal falls within permissible range.

Keywords: Dumpsites, pedology, soil, heavy metals, nutrients, physiochemical properties

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