The European Research Journal

The European Research Journal

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  • Publisher: The Association of Health Research & Strategy
  • Country of publisher: turkey
  • Date added to EuroPub: 2019/Nov/07

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  • Language of fulltext: english
  • Time from submission to publication: weeks

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  • Year open access content began: 2015
  • Does the author retain unrestricted copyright? False
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This journal has '381' articles

Nonapoptotic cell death induced by Hypericum species on cancer cells

Nonapoptotic cell death induced by Hypericum species on cancer cells

Authors: Ferda Ari, Nazlihan Aztopal, Merve Erkisa, Serap Celikler, Saliha Sahin, Engin Ulukaya
Year: 2017, Volume: 3, Number: 1
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Abstract

Objective. There are approximately 400 Hypericum species that grow naturally in different geographic origins of the world. Those species have been used in different folk medicines and screened for their biological activity including cancer. Our country is an important place for Hypericum species which are known as “kantaron, binbirdelik otu, kan otu, kılıç otu, yaraotu, kuzukıran”. We therefore evaluated the possible cytotoxic/apoptotic activities, total phenolic content and antioxidant capacity of the crude methanol extracts Hypericum adenotrichum Spach. and Hypericum olympicum L. which are still used in Turkish folk medicine. Methods. The total phenolic content and antioxidant capacity were determined by Folin-Ciocalteu and ABTS methods. Anti-growth effects were screened in human hepatoma (Hep3B) and rat glioma (C6) cell lines by the MTT and ATP viability assays. The cell death mode (apoptosis/necrosis) was investigated by fluorescence imaging and the level of caspase-cleaved cytokeratin 18 (M30), active caspase-3 and cleaved PARP (poly (ADP-ribose) polymerase). Results. The results indicate that the crude methanol extracts of Hypericum olympicum L. and Hypericum adenotrichum have both anti-growth/cytotoxic activities on these cells in a dose dependent manner. Conclusion. These extracts clearly induced non-apoptotic cell death in human hepatoma (Hep3B) and rat glioma (C6) cell lines.

Keywords: Hypericum olympicum, Hypericum adenotrichum, cell death, necrosis
Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats

Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats

Authors: Sedat Dogan, Hasmet Yazici, Esin Yalcinkaya, Halil Ibrahim Erdogdu
Year: 2017, Volume: 3, Number: 1
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Abstract

Objective. The aim of the present study was to investigate the protective role of selenium against cisplatin-induced oral mucositis in rats. Methods. Healthy wistar albino rats (n=21) were randomly divided into three groups: Cisplatin (Cis), cisplatin and selenium (Cis+Se) and control (C). Cisplatin was administered for 3 days to Cis and Cis+Se groups. Cis+Se group received selenium 5 days before cisplatin injection and continued for 11 consecutive days. Malondialdehyde (MDA) levels of the rats were determined before and at the end of experimental protocol. The tongues of rats were harvested for immunuhistochemical examinations. Results. In biochemichal analysis, MDA levels significantly increased in the Cis group (p=0.018). On the contrary, there was no significant difference between pretreatment and posttreatment MDA levels in Cis+Se group (p=0.128). In the immunohistochemical examinations of lingual tissues stained with anti-caspase-3, when the Cis and Cis+Se groups were compared, there were significantly more immunopositivity in the Cis group and significantly less immunopositivity in the Cis+Se group (p<0.05). Conclusions. Selenium might have played a protective role against cisplatin-induced oral mucositis in rats. Further studies are necessary before its clinical use in patients.

Keywords: Cisplatin; oral mucositis; selenium; toxicity
The role of metformin on serum vitamin B12 levels in patients with type 2 diabetes mellitus

The role of metformin on serum vitamin B12 levels in patients with type 2 diabetes mellitus

Authors: Mitra Niafar, Behrad Jamali, Nasrin LotfiBakhshaiesh, Naser Aghamohammadzadeh, Nader Nader
Year: 2015, Volume: 1, Number: 1
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Abstract

Objective. To evaluate the vitamin B12 (VB12) deficiency in patients with type-2 diabetes mellitus (DM-2) using metformin or other hypoglycemic agents. Methods. 400 patients with DM-2 were divided into two arms (N=200/group); 1) those receiving metformin (MET) for at least six months and 2) those receiving hypoglycemic agents other than metformin (OHA). Serum VB12 concentrations were measured. Data were analyzed by using two-sample t-test for numerical data and chi-square with logistic regression analysis for categorical data. Numerical values were expressed as means ± standard deviations. Null hypotheses were rejected at P-values <0.05. Results. Definite biochemical VB12 deficiency (<148 pmol/L) was found in 29/200 (14.5%) of the MET group while it was observed in 4/200 (2%) in the OHA group (P<0.001). Similarly, possible VB12 deficiency (serum concentrations <185 pmol/L) was found in 39 (19.2%) of the MET group and 12 (6%) in the OHA group (p<0.001). There was positive correlation between low VB12 level and metformin administration (R2=0.26, p<0.001). Conclusion. Patients with DM-2 on metformin had lower VB12 levels than those on other hypoglycemic drugs. The relation between VB12 deficiency and metformin therapy indicates the need for periodic measurement of serum VB12 levels in patients treated with metformin.

Keywords: Oral medications, type-2 diabetes, metabolic syndrome, HbA1C, diabetic neuropathy
The effect of perimenopausal estrogen levels on depression and anxiety: a pilot study

The effect of perimenopausal estrogen levels on depression and anxiety: a pilot study

Authors: Buket Belkiz Gungor, Mahmut Gungor, Ibrahim Taymur, Rustem Askin, Hakan Demirci, Yakup Akpinar, Almila Ikra Akgul
Year: 2015, Volume: 1, Number: 1
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Abstract

Objectives. Among women in the perimenopausal period, rapid hormonal changes can be seen. In the present study, we aimed to investigate the relationship between depression, anxiety and changing estrogen hormone levels at menopause. Materials and Methods. The research group was composed of 30 perimenopausal women who had FSH levels higher than 20 IU and irregular menses. Anxiety and depression status was assessed with the Hospital Anxiety and Depression Scale. Patients with or without depression or serious anxiety were compared in terms of age, body mass index (BMI), hot flushes, smoking, premenstrual syndrome (PMS) and estrogen levels. Results. There were no statistically significant differences in terms of hot flushes, BMI, smoking, age, and PMS in patients with or without depression/anxiety. Estrogen levels were statistically significantly lower in the group with depression compared to the group without depression (p=0.026). Conclusion. We believe that falling levels of estrogen in the perimenopausal period can be considered to be a risk factor for depression. The possible role of estrogen replacement in the treatment of depression and anxiety should be investigated in further studies.

Keywords: Perimenopause, depression, anxiety, FSH, estrogen
The effect of endoscopic sinus surgery on quality of life: a prospective clinical study

The effect of endoscopic sinus surgery on quality of life: a prospective clinical study

Authors: Zeynep Sayar, Mehmet Haksever, Davud Akduman, Sundus Aslan, Fevzi Solmaz, Ahmet Kaygusuz
Year: 2015, Volume: 1, Number: 1
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Abstract

Objective. Chronic rhinosinusitis has a negative effect on quality of life of millions of involved patients. The aim of this study was to assess the effect of endoscopic sinus surgery on the quality of life in patients with chronic rhinosinusitis. Material and Methods. Twenty-five cases with chronic rhinosinusitis, which were resistant to 12 weeks medical treatment, have undergone Endoscopic Sinus Surgery. Two kinds of health related quality of life (HRQoL) surveys (Chronic Sinusitis Survey, Rhinosinusitis Disability Index) were applied to all cases before and at least 6 months after at the operation. Lund-Kennedy endoscopic scoring system was used as an objective evaluation. All analysis was performed using SPSS statistical software. Results. Statistically significant improvements were computed for cases before and after surgery regarding the Chronic Sinusitis Survey symptom scores (p<0.05). Also Statistically significant improvements were found for cases regarding the Rhinosinusitis Disability Index. But mean changes in endoscopic scores did not statistically correlate with changes in quality of life (p>0.05). Conlusions. Our results showed that endoscopic sinus surgery improves quality of life in cases with chronic rhinosinusitis. But this improvement did not correlate with the endoscopic scores of paranasal sinuses.

Keywords: Chronic rhinosinusitis, endoscopic sinus surgery, chronic sinusitis survey, rhinosinusitis disability index, quality of life
Chondral lesion of capitellum humeri accompanying radial head fracture: a case report

Chondral lesion of capitellum humeri accompanying radial head fracture: a case report

Authors: Murat Songur, Ercan Sahin, Mahmut Kalem, Sinan Zehir
Year: 2015, Volume: 1, Number: 1
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Abstract

In this case report we present a case of full thickness chondral lesion of anterior-distal surface of capitellum humeri, accompanying an intra-articular radial head fracture. Importance of this case is the resemblance of chondral injury to Lorenz-Kocher lesion of humerus and atypical displacement of chondral fragments. A 32-year-old male, admitted to emergency room after fall on his right upper extremity. X-ray and CT scan of elbow revealed a minimally displaced radial head fracture (Mason type 2), with a 4 mm step (depression) at joint surface. During the operation, at the anterior surface of the distal humerus, a full thickness chondral lesion was encountered. After removal of chondral fragments from the fractured radial head surface, it was seen that these fragments were of capitellar origin. Following radial head fixation, early active assistive motion was started. At the 6 month visit, the patient was pain-free with full participation in activities of daily living with a DASH score of 12,5. This injury is important due to demonstration of such an extensile injury in spite of benign looking radiology. Although radial head fractures were described, these type of occult injuries may be responsible from unexplainable and unfavorable outcome following low energy radial head fractures, treated conservatively.

Keywords: Cartilage lesion, radial head fracture
Renal angiosarcoma: a rare case report

Renal angiosarcoma: a rare case report

Authors: Cemil Hocazade, Mutlu Dogan, Yakup Bozkaya, Fatma Malkoc
Year: 2015, Volume: 1, Number: 1
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Abstract

Angiosarcomas constitute about 2% of all sarcomas and generally are worst prognostic subtype of soft tissue sarcomas. Angiosarcomas are very aggressive tumors and one year after diagnosis half of patients dies with metastasis of lung, lymph nodes, bone and soft tissue. Diagnosis can accurate with immunochemistry stain, such as factor 8 related antigen, CD 31, CD 34 and von Villebrand factor. Our patient was a 61-year-old women who died four months after symptoms appeared with extensive metastasis. She was able to receive chemotherapy for only one course and after that treatment was changed to palliative.

Keywords: Angiosarcoma, renal, metastasis
The factors affecting surgical success rate for the patients with congenital esotropia

The factors affecting surgical success rate for the patients with congenital esotropia

Authors: Tugba Goncu, Funda Dilmen, Ali Akal, Fatih Mehmet Adibelli, Sevinc Cakmak
Year: 2015, Volume: 1, Number: 2
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Abstract

Objective. To evaluate the factors and preoperative clinical features affecting surgical success rate in patients with congenital esotropia. Method. The medical files of patients who underwent surgery for congenital esotropia between June 2012 and September 2014 were retrospectively reviewed. Data from the patients’ full ophthalmological examination included visual acuity, ocular alignment, duction, versions and sensory tests for binocularity, cycloplegic retinoscopy and fundus evaluation. Presence of previous ambliyopia treatment, fixation preference, cross-fixation, anisometropia >1.5D, ocular motility abnormalities were noted. The relationship of these variables with the surgical success rate was evaluated. Results. A total of 48 patients (25 female,52.1%) were included. The mean age of the patients was 4.4±5.2 years. Successful surgical outcome was achieved in 39 (81.3%). All the patients were followed for 14.1±4.4 months. There was no relation between surgical success and patients’ gender, positive family history, consanguinity, previous ambliyopia treatment, anisometropia, abnormal ocular motility and cross-fixation and mean cycloplegic refraction (p>0,05). However, fixation preference and mean preoperative deviation found to be related with surgical failure (p<0,05). Conclusion. In this study many variables such as epidemiologic characteristics and clinical features of patients were investigated for their possible association with surgical success rate. Only preoperative fixation preference without ambliyopia and mean preoperative deviation were found to be risk factors for the surgical failure in this group of patients with infantile esotropia.

Keywords: Congenital esotropia, surgical success, ambliyopia, anisometropia, fixation preference
Carotid endarterectomy: a comparison on general and local anesthesia

Carotid endarterectomy: a comparison on general and local anesthesia

Authors: Faruk Toktas, Tugrul Goncu, Suleyman Surer, Gunduz Yumun, Kadir Kaan Ozsin, Burak Erdolu, Senol Yavuz, Arif Gucu
Year: 2015, Volume: 1, Number: 2
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Abstract

Objective. Carotid endarterectomy (CEA) reduces disabling or fatal stroke risk in patients with significant carotid stenosis. The aim of this study was to compare the results of CEA performed under general anesthesia (GA) or local anesthesia (LA) in patients with symptomatic severe carotid artery stenosis. Method. We retrospectively collected the data on 64 patients who underwent CEA under GA (47 patients) and LA (17 patients) at our hospital from January 2010 to January 2014. All clinical, demographics, preoperative risk factors and postoperative data were compared for postoperative results. Surgical indications, techniques, and complications were also compared. Results. The groups were similar for age, gender and preoperative risk factors. There were no significant differences in death (GA: 4.2% vs. LA: 0%; p =1.0), stroke (GA: 4.2% vs. LA: 0%; p=1.0), death/ stroke rate (GA: 2.1% vs. LA: 0%; p=1.0), nerve injury (GA: 2.1% vs. LA: 5.8%; p=0.464), saphenous vein patch closure (GA: 83% vs. LA: 59%; p=0.051), shunt rate (GA: 8.5% vs. LA: 6 %; p=1.0), hospital stay (GA: 8.2±5.7 day vs. LA: 6.2±2.9 day, p=0.275), hematoma rate (GA: 0 %vs. LA: 5.8%; p =0.266) and transient ischemic attack rate (GA: 4.2% vs. LA: 0%; p=1.0) between the two techniques. Mortality occurred in two patients (both in the GA group) due to stroke and myocardial infarction. Conclusion. Carotid endarterectomy performed safely under general or local anesthesia is associated with low morbidity and mortality rates. Local anesthesia can be a safe option for evaluating the better neurological status during operation.

Keywords: Carotid endarterectomy, general anesthesia, local anesthesia, carotid artery stenosis
Red cell distribution width, other hematological parameters and atherogenic index of plasma in patients with clopidogrel and aspirin resistance

Red cell distribution width, other hematological parameters and atherogenic index of plasma in patients with clopidogrel and aspirin resistance

Authors: Yasemin Ustundag Budak, Kagan Huysal, Sanem Karadag Gecgel, Hasan Ari, Mehmet Melek, Senol Yavuz, Sencer Camci, Alper Karakus, Ibrahim Aktas, Selma Ar...
Year: 2016, Volume: 2, Number: 3
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Abstract

Objective. Chronic inflammation might favour platelet hyperactivity, which leads to inter-individual variability in antiplatelet resistance. The aim of this study was to test the hypothesis that there is a relationship between some hematological parameters reported as measures of systemic inflammation, the atherogenic index of plasma (AIP), and antiplatelet responsiveness. Methods. This retrospective study included patients receiving aspirin (100 mg) and clopidogrel (75 mg) daily before and after stenting. Platelet inhibition was assessed using the VerifyNow P2Y12 point-of-care test. Resistance to antiplatelet therapy was defined as P2Y12 reactivity exceeding 240 units (for clopidogrel) or aspirin reaction units exceeding 550 units (for aspirin). The AIP was calculated as the logarithm of triglyceride/high density lipoprotein cholesterol. The white blood cell (WBC), platelet (P), neutrophil (N), and lymphocyte (L) counts, red cell distribution width (RDW), hemoglobin (Hb), plateletcrit, mean platelet volume (MPV), platelet distribution width, and N/L and P/L ratios were evaluated. Results. Of 232 patients (73% male; median age, 63 years; range, 38-87 years), 52 (22%) were aspirin resistant and 82 (35%) were clopidogrel resistant; 7.7% were both aspirin and clopidogrel resistant. Median RDW levels were significantly higher (14.4% [interquartile range (IQR) 3] vs. 13.9% [IQR 1.3]; p=0.01) and Hb levels significantly lower (12.0±1.6 g/dL vs. 13.2±1.7 g/dL; p<0.001) in the clopidogrel-resistant patients than in the clopidogrel responders. WBC, AIP, MPV, N/L, and P/L ratios were not statistically significant (p>0.05). Multivariate logistic regression showed that Hb (odds ratio [OR]=0.73; 95% confidence interval [CI], 0.60-0.88; p=0.001) and RDW (OR=1.26; 95% CI, 1.02-1.55; p=0.02) were independent predictors of clopidogrel resistance. Conclusion. Both RDW and Hb were independent variables associated with clopidogrel resistance, but antiplatelet resistance cannot be predicted based on other hematological parameters or AIP.

Keywords: Red cell distribution width,hematological parameters,atherogenic index of plasma,systemic inflamation,clopidogrel resistance References
Establishing reference values and evaluation of an in-house ferric reducing antioxidant power (FRAP) colorimetric assay in microplates

Establishing reference values and evaluation of an in-house ferric reducing antioxidant power (FRAP) colorimetric assay in microplates

Authors: Yasemin Ustundag, Kagan Huysal, Serdar Kahvecioglu, Hakan Demirci, Senol Yavuz, Murat Sambel, Dursun Unal
Year: 2016, Volume: 2, Number: 2
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Abstract

Objective. The total antioxidant capacity (TAC) of a sample can be measured with a ferric reducing antioxidant power (FRAP) assay. There are commercially available kits for FRAP assays, however they are more expensive than in-house kits. We aimed to evaluate a FRAP direct measurement method under our laboratory conditions using a microplate reader and establish reference values to use in future research projects. Methods. An in-house microplate adaptation of the FRAP method was evaluated. Reference values of FRAP were established for one hundred and twenty subjects aged between 25-55 years. FRAP levels were estimated in 30 serum samples with high glucose concentration, 44 hyperbiluribinemic neonatals and 16 patients receiving renal replacement therapy (RRT). Results. The mean FRAP level was 890±235 µmol/L. The median TAC level was 904 µmol/L. This method was found to be linear up to at least 2000 µmol/L. The intra- and inter-assay coefficients of variation were 2.7-6.7% and 5.3-10.1%, respectively. The mean FRAP level was lower than normal in diabetes and RRT patients and higher in hyperbiluribinemic neonatals (687±209 µmol/L, 609±250 µmol/L and 945±187 µmol/L, respectively). Conclusions. Our reference values give comparable results with the literature. This method is simple, reliable, and inexpensive. It could be used for studies of oxidative stress-related diseases.

Keywords: Total antioxidant capacity,ferric reducing antioxidant power assay; evaluation; reference range; microplate
Clinical assessment of the severity of chronic hand eczema: correlations between six assessment methods

Clinical assessment of the severity of chronic hand eczema: correlations between six assessment methods

Authors: Nilay Duman, Erol Uzunali
Year: 2015, Volume: 1, Number: 2
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Abstract

Objective. The severity of hand eczema (HE) can be assessed via numerous methods, however, a standard method remains lacking. Furthermore, correlations between the various methods are not known. The purpose of the study was to evaluate the correlations between six different methods used for assessing the severity of chronic HE. Method. The study included 100 patients with chronic HE. The severity of HE was assessed using the Hand Eczema Severity Index (HECSI), Physician Global Assessment (PGA), Dermatology Life Quality Index (DLQI), Photographic Guide (PG), Osnabrueck Hand Eczema Severity Index (OHSI), and Investigators’ Global Assessment (IGA). Furthermore, correlations between the 6 methods were determined. Results. There was a strong correlation between HECSI, and OHSI, mTLSS, PG, and IGA, and between IGA, and PG and OHSI (P < 0.001). There was a moderate correlation between DLQI and PGA (P < 0.001), whereas correlations between DLQI and the other scales were weak. The females had lower quality of life, although gender was not associated with disease severity according to the other scales. Conclusion. Overall, the six methods used for assessing the severity of HE were significantly positively correlated. Females had lower quality of life, but the severity of HE assessed via the other five scales did not vary according to gender. The weakest correlation was between DLQI and all other scales.

Keywords: Chronic hand eczema, severity, quality of life
Differential diagnosis and proper approach for ophthalmomyiasis externa: an experience of 12 patients

Differential diagnosis and proper approach for ophthalmomyiasis externa: an experience of 12 patients

Authors: Gulsah Usta, Melisa Zisan Karslioglu, Ramazan Adanir
Year: 2015, Volume: 1, Number: 2
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Abstract

Objective. To evaluate the differential diagnosis and therapy of patients who had ophthalmomyiasis externa, which is a self-limiting parasitic disease and is formed as a result of infestation of ocular surface with myiasis flies. Method. A retrospective study. Results. In our series we evaluated 12 patients attending intense eyelid edema and mimicking an acute catarrhal conjunctivitis, with symptoms of burning, stinging, itching, and increase in lacrymation as well as the sense of foreign body moving in the eye. After further biomicroscopic examination 1 – 2 mm size of mobile, black headed transparent larvae were seen. After mechanical removal of larvae from the eye, topical antibiotic and mild steroid drops were sufficient for improvement. Conclusion. We hereby want to emphasize the importance of careful examination and detailed anamnesis even in conjuncitivitis cases.

Keywords: Conjunctivitis, oestrus ovis, ophthalmomyiasis

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