International Journal of Medical Research and Review

International Journal of Medical Research and Review

Basic info

  • Publisher: Siddharth Health Research and Social Welfare Society
  • Society/Institution: Siddharth Health Research and Social Welfare Society
  • Country of publisher: india
  • Platform/Host/Aggregator: Open journal system ojs
  • Date added to EuroPub: 2019/Nov/08

Subject and more

  • LCC Subject Category: Medicine, Obstetrics & Gynecology, Internal Medicine, Biomedicine, Anatomy, Anesthesiology, Radiology, Nuclear Medicine & Medical Imaging, Otolaryngology, Microbiology
  • Publisher's keywords: Medicine, internal Medicine, Pathology, Physiology, Imaging and Radiology, Anesthesiology
  • Language of fulltext: english

Publication charges

  • Article Processing Charges (APCs): Yes Rs. 4000/-
  • Submission charges: No
  • Waiver policy for charges? Yes

Editorial information

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2013
  • Does the author retain unrestricted copyright? True
  • Does the author retain publishing rights? True

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Other
  • Deposit policy registered in: None

This journal has '596' articles

Comparison of dynamic hip screw and proximal femoral nail in the
treatment of Intertrochanteric fracture of femur

Comparison of dynamic hip screw and proximal femoral nail in the treatment of Intertrochanteric fracture of femur

Authors: Prakash D Samant, Sachin Y Kale, Shikhar D Singh, Prasad Chaudhari, Sanjay B Dhar, Nabakrishna Gohain Gohain
( 0 downloads)
Abstract

Introduction: As the elderly population grows, the number of hip fractures continues to increase. This study aims to compare the clinical outcomes of DHS and PFN in the fixation of intertrochanteric fracture of femur. Methodology: After obtaining approval of the ethics committee, a prospective study was conducted in the Department of Orthopedics, DY Patil School of Medicine from January 2014 till December 2015. Informed consent was taken from from patients who fulfilled the inclusion/exclusion criteria and relevant clinical information was collected, including intra and post-operative details. The patients were called for followup to check for complications. Results: During the study period, 50 patients with intertrochanteric fracture were included in the study, of which 23 were treated ith PFN and 27 with DHS. 76% of the PFN patients needed no blood transfusion, while 41% of DHS patients needed 2 units of blood transfusions. Post operative fever and deep vein thrombosis was more common in DHS patients. 79% of PFN patients started mobilizing on the first postoperative day as compared to 68% of DHS patients who starting mobilizing on third postoperative day. Similarly post operative weight, full weight bearing and return to activity of daily living was seen to be better in PFN patients. Conclusions: Our study showed that PFN is a superior method of osteosynthesis as compared to DHS in the treatment of intertrochanteric fractures. Future research should focus on studying the economic and rehabilitative impact of PFN on patients with intertrochanteric fractures.

Keywords: Complications, Dyanamic hip screw, Intertrochanteric fracture
Immunocytochemical staining of cervical smears – A comparative
study with routine cytology for confirmation of precancerous and
cancerous lesions of cervix

Immunocytochemical staining of cervical smears – A comparative study with routine cytology for confirmation of precancerous and cancerous lesions of cervix

Authors: Varsha Pandey, Manju Raj Purohit, P. L. Dhand
( 0 downloads)
Abstract

Introduction: Carcinoma cervix is one of the leading causes of morbidity and mortality. The most effective method of screening is based on Pap smear study. However, Pap smear has relatively low sensitivity and irreducible false negative & false positive rates. In countries like India, it is not always feasible to follow the patient for confirmation by histology. In the present study, we have tried to fill this gap by staining the cervical smears with, epithelial cell markers including CK17 and CEA expressed by dysplastic squamous cells. Materials & Methods: 50 cervical smears reported as precancerous or cancerous were stained with anti CK17 and anti CEA. The patients were followed for histopathology. Results: Out of 20 cases of ASCUS, three were positive both for anti-CK17 and anti-CEA and six were positive for anti- CK17 only. Out of 18 cases of LSIL, nine were positive for both anti-CK17 and anti-CEA and fifteen were positive for anti-CK17 only. Out of eight cases of HSIL, three were positive for both anti-CK17 and anti-CEA and six were positive for anti-CK17 only. Out of 4 cases of SCC, three were positive for both anti-CK17 and anti-CEA and all four were positive for anti-CK17. Conclusion: Positive result in staining was higher in high grade lesions. CK 17 was found to be better marker than CEA. CK17 and CEA can be used as adjunct to Pap smear screening but its high cost may restrict its use in routine.

Keywords: Cervical Smears, Immunocytochemistry, CK 17, CEA
Prevalence of thyroid dysfunction: Experience of a tertiary care centre
in Kerala

Prevalence of thyroid dysfunction: Experience of a tertiary care centre in Kerala

Authors: Lakshminarayana Gopaliah, Sheetal Lakshminarayana, Nidhish P Sadanandan, Pramod M
( 0 downloads)
Abstract

Background: There is limited data regarding the prevalence of thyroid disorders in India, and this is the first study to assess their prevalence in northern Kerala. Methods: All subjects who underwent blood sampling for estimation of thyroid function tests (TFTs) on their initial visit to the EMS Memorial Cooperative Hospital and Research Centre, Perinthalmanna (2009-2013) were included in the study. Results: The study population included 8179 subjects (Males: 3205, females: 4974), of ages from 1-94 (Mean-41.95) years of age. The overall prevalence rate of thyroid function abnormalities was 15.73%; more in females (16.91 %) than males (13.90%). The subclinical hypothyroidism (SCH) was the commonest thyroid abnormality (7.15 %) followed by overt hypothyroidism (4.2%), hyperthyroidism (2.77 %) and subclinical hyperthyroidism (SH) (1.6 %). The prevalence rate of hypothyroidism in different age groups was 2.81 % in 1-19, 3.53 % in 20-45 and 5.36 % in those ≥ 46 years respectively. The prevalence rate of SCH was highest (8.05 %) in the age group of 20-45 years followed by 6.74 % in ≥ 46 and 4.19 % in 1-19 years. Conclusions: The thyroid function abnormalities are common and the prevalence is higher in females than males. The prevalence rates of thyroid function disorders were 9.76%, 17.50 % and 15.05 % in age groups of 1-19, 20-45 and ≥ 46 years respectively. The SCH was the commonest abnormality, followed by overt hypothyroidism, hyperthyroidism and SH; first 3 conditions were more common in females than males, whereas last was common in males.

Keywords: Hypothyroidism, Hyperthyroidism, Subclinical Hypothyroidism, Subclinical Hyperthyroidism
Knowledge and attitude of Al-Ghad college students towards corona
virus infection

Knowledge and attitude of Al-Ghad college students towards corona virus infection

Authors: Haytham M. Hassan
( 0 downloads)
Abstract

Objective: This study was conducted to identify the knowledge, attitudes and beliefs towards Corona virus infection among students in Al-Ghad International College for Applied Medical Science in Riyadh Male Campus. Methods: Using a descriptive cross-sectional method, data were collected from 220 sample students, using a simplified, structured, selfadministered questionnaire, including closed questions completed by students in their classes. Results: The findings indicate that most students gave correct answers to questions related to disease prevention and control while the lowest percent was observed in questions related to mode of transmission, whereas questions related to the general knowledge about corona virus and the clinical picture of disease have intermediate percents of correct answers. Students’ knowledge status was positively associated with their age category. Most of the students get their information about the corona virus from websites (internet) followed by TV and friends. Also, most of the students agreed that corona is a fatal virus and it’s dangerous to the community, diseased people must be isolated, health education campaigns decrease the virus transmission and the necessary measures for disease control were taken by the responsible authority. Conclusion: This study gives an idea about the effect of interventional activities against corona virus infection and areas that needs further efforts to control the spread of the virus transmission.

Keywords: Alghad College; Attitude; Corona virus; Knowledge
Outcome of routine testing for HCV and HBV in patients attending
and admitted in various surgical units of a tertiary care institute

Outcome of routine testing for HCV and HBV in patients attending and admitted in various surgical units of a tertiary care institute

Authors: Raminder Sandhu, Shalley Dahiya, Bijender Singh, Ramnika Aggarwal, Gaurav Sharma
( 0 downloads)
Abstract

Background: Hepatitis B and C virus remain leading causes of morbidity and mortality. Unfortunately, once inflicted, these infections show poor response to the available treatment modalities. So the focus remains on preventive strategies, to avoid spread of infection. There is lack of routine serological screening prior to surgery which is one of the factors responsible for increased disease transmission. Material and Methods: The present study involved retrospective analysis of 9272 routine blood samples from all ages and both sexes who were attending and admitted in different surgical departments. These patients were screened by rapid immunochromatographic assay for qualitative detection of anti- HCV antibodies and HBsAg to know their carrier status prior to any surgical intervention. Results: Out of 9272 samples tested, 155 (3.6%) tested positive for anti- HCV antibodies and 162 (3.26%) for HBsAg. Seroprevalence of HCV was 3.77 %( 96) and 3.36% (59) in male and female respectively, with preponderance among age group of 41-60 (43.87%) and 21- 40 years (39.35%). HBsAg detection revealed seropositivity of 3.89 %( 93) in males; 2.67 %( 69) in females, with predominance in young adults of 21-40 (43.83%) followed by 41-60 (24.07%) years. Maximum number of seropositive cases for both HCV and HBV were from General surgery department as 63.23% & 53.09% respectively. Conclusion: The study estimated high prevalence of HBV and HCV on routine screening of patients reporting to various surgical departments. Healthcare providers have significantly high risk of infectivity along with further transmission of the disease if pre-operative screening and standard precautions are not followed strictly.

Keywords: Anti- HCV antibodies, HBsAg, Seroprevalence, Surgical Units
Clinical study of coparision of pterygium surgery with and without
Mitomycin-C on bare sclera technique

Clinical study of coparision of pterygium surgery with and without Mitomycin-C on bare sclera technique

Authors: Mohan Lal Gupta, Ravindra Kumar Meena, Veena Bhardwaj
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Abstract

Introduction: A pterygium is a triangular wedge of fibro-vascular conjunctival tissue that appears on the epibulbar conjunctiva, which can be removed by various methods. Recurrence of Pterygium after exicision is a very common problem encountered by ophthalmologist. Several methods have been suggested to avoid these recurrences. We studied the recurrence rate of pterygium after application of intraoperative mitomycin C (0.04%). Method: This is a retrospective study of fifty eyes in fifty patients who underwent pterygium excision by the same surgeon using intraoperative topical mitomycin C (25 patients) and without using mitomycin c(25 patients) during September 20014— September 2015 in the ophthalmology department at Jhalawar medical college, Jhalawar, Rajasthan. 0.04% Mitomycin applied to bare sclera after excision for two minutes by swab sticks. Postoperative follow up period was 6 months. Outcomes measured in the form of recurrence and complications were analyzed. Results: In Group A with use of mitomycin C there was no recurrence after 6 months follow-up while in Group B recurrence was seen in 5 patients within 3-6 months, however in group A 1 patient had scleral thinning. Conclusion: Intraoperative administration of mitomycin C 0.04% is safe and effective to prevent pterygium recurrences.

Keywords: Bare Sclera, Mitomycin C, Pterygium, Recurrence
A quadrupled semitendinosus only anterior cruciate ligament
reconstruction with tibial suspensory fixation

A quadrupled semitendinosus only anterior cruciate ligament reconstruction with tibial suspensory fixation

Authors: Madan Mohan Ballal, Pavankumar Chebbi
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Abstract

Purpose: Study is designed to analyze the postoperative outcome of arthroscopic ACL reconstruction with quadrupled semitendinosus tendon autograft fixed in femoral tunnel using tight rope and in the tibial tunnel using suture disc. Methods: A prospective study on a continuous series of 102 patients, operated for ACL rupture, using the same technique, from September 2010 to March 2013. Results:The longest follow-up was at 24 months. At 2 year follow-up the mean International Knee Documentation Committee (IKDC 1999)evaluation score revealed that 63.7% had a normal overall grade A. The mean Lysholm score improved from 59.4 to 92.4 at follow-up. The improvement in the limb symmetry index by single hop test was statistically significant. Laxity assessment at 12 months showed 87.2% had a grade 0 or 1 Lachman laxity with a hard end point. Patients had no motion deficit and the knee was stable in deep flexion and retained their strength during internal rotation of the knee. Conclusion: a quadrupled semitendinosus graft was adequate in order to be used alone as a four-strand graft and to get a minimum length and thickness for our graft construct. This enhanced our post-operative rehabilitation by contribution to stability in deep flexion and retaining the strength during internal rotation of the knee. It is cost effective to use atightropeat the femoral end and suture disc at the tibial end as compared to an aperture fixation by a bioscrew.

Keywords: Purpose: Study is designed to analyze the postoperative outcome of arthroscopic ACL reconstruction with quadrupled semitendinosus tendon autograft fixed in femoral tunnel using tight rope and in the tibial tunnel using suture disc. Methods: A prospective study on a continuous series of 102 patients, operated for ACL rupture, using the same technique, from September 2010 to March 2013. Results:The longest follow-up was at 24 months. At 2 year follow-up the mean International Knee Documentation Committee (IKDC 1999)evaluation score revealed that 63.7% had a normal overall grade A. The mean Lysholm score improved from 59.4 to 92.4 at follow-up. The improvement in the limb symmetry index by single hop test was statistically significant. Laxity assessment at 12 months showed 87.2% had a grade 0 or 1 Lachman laxity with a hard end point. Patients had no motion deficit and the knee was stable in deep flexion and retained their strength during internal rotation of the knee. Conclusion: a quadrupled semitendinosus graft was adequate in order to be used alone as a four-strand graft and to get a minimum length and thickness for our graft construct. This enhanced our post-operative rehabilitation by contribution to stability in deep flexion and retaining the strength during internal rotation of the knee. It is cost effective to use atightropeat the femoral end and suture disc at the tibial end as compared to an aperture fixation by a bioscrew.
Nondescent vaginal hysterectomy, a changing practice in Indian scenario for scar less surgery

Nondescent vaginal hysterectomy, a changing practice in Indian scenario for scar less surgery

Authors: Sangam Kumari, Nishi Mitra, Sashibala Shrivastava
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Abstract

Introduction: Hysterectomy is the most common operation performed next only to caesarean operation by gynaecologist. This decade has seen resurgence of hysterectomy by vaginal route for indication other than prolapse, may be due to better compliance by the patients. Aims and objective: This prospective observational study was conducted to assess safety, morbidity, and feasibility of nondescent vaginal hysterectomy. Method: All patients who fulfilled the criteria for the study were included in the study. NDVH was performed in the cases with adequate vaginal access, good uterine mobility and uterine size not exceeding 18 weeks. Different morcellation techniques were employed for bigger size uterus. Result: Total 50 patients underwent nondescent vaginal hysterectomy. 28 out of 50 patients were in 40 -49 years of age group. 98% of them were multiparous. Dysfunctional uterine bleeding (44%) was the most common indication followed by Pelvic inflammatory disease (26%). Morcellation techniques were employed in 33 cases (66%). Mean operating time was 79.6 minutes with average blood loss 110 ml and average duration of pain disappearance was on 4th day and hospital stay 6 days. Complications were minimal. Conclusion: Vaginal hysterectomy in non descended uterus is feasible, safe, associated with less morbidity and better compliance by patients.

Keywords: Nondescent Vaginal Hysterectomy, Morccellation, Vaginal hysterectomy
Significance of thrombocytopenia in different types of malaria

Significance of thrombocytopenia in different types of malaria

Authors: Meenai FJ, Jalaly, T, Khairkar P,, Narkhede v
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Abstract

Introduction: Malaria is a major health problem in India. It usually presents with thrombocytopenia, Study was conducted to assess the presence and severity of thrombocytopenia in malaria- fever. This study was done in at tertiary care teaching hospital associated with medical college. Method: A total of 120 patients with acute febrile illness and positive for malaria parasite were included. They all are positive for malaria parasite on peripheral smear examination with leishmans stain on conventional microscopy. Platelet count was done on a fully automated, hematology analyzer. Results: Thrombocytopenia was observed in 100% cases of malaria caused by P. Falciparum and 69.79% cases of malaria caused by P Vivax. Overall 85.83% of patients with acute febrile illness due to malaria showed thrombocytopenia. Conclusion: Thrombocytopenia is a common finding in malaria- fever, but its presence is not a distinguishing feature between Pl. vivax and Pl. falciprum. Our study noted the importance of thrombocytopenia as an indicator of malaria in acute febrile illness.

Keywords: Malaria, Thrombocytopenia, P. falciparum, P. vivax
Assessment of effectiveness of nonspecific antidiarrheal agents in
reducing the need for intravenous rehydration in children with acute
diarrhea

Assessment of effectiveness of nonspecific antidiarrheal agents in reducing the need for intravenous rehydration in children with acute diarrhea

Authors: S. Bhuvaneshwari T. Shanmugham, Suresh V . Dange,, Madhukant H. Nandagavli, Madhav M. Mutalik
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Abstract

Background: In clinical practice, nonspecific antidiarrheals are most commonly used by clinicians along with routine treatment to hasten the recovery and to give psychological reassurance. This study was conducted to assess the effectiveness of nonspecific antidiarrheal agents in reducing the need for intravenous rehydration in children with acute diarrhea. Materials and Methods: This was a prospective, observational study done in clinical settings for a period of 3 years at two pediatric clinics and at a tertiary care hospital. Children were divided into 5 treatment groups (viz, control, racecadotril, Mebarid, Diarex and loperamide) at the discretion of the pediatrician. One questionnaire was provided to parents to record the details about the course of diarrhea. Parents were sensitized to report any episode of complication or need for intravenous fluids. Results: The unscheduled need for intravenous fluids due to dehydration was significantly higher in control group compared to other groups {Control: 7.37%, Racecadotril : 1.71% Mebarid: 2.4%, Diarex: 0%, Loperamide : 0%)}. Conclusion: Present study suggests that use of nonspecific antidiarrheals may decrease the need for admission for intravenous fluids in children with acute diarrhea.

Keywords: Acute diarrhea, Diarex, Loperamide, Mebarid, Nonspecific antidiarrheals, Racecadotril
Oxidative stress during spontaneous vaginal delivery: comparison
between maternal and neonatal oxidative status

Oxidative stress during spontaneous vaginal delivery: comparison between maternal and neonatal oxidative status

Authors: Chitra M,, Mathangi D, C, Priscilla Johnson
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Abstract

Introduction: Spontaneous vaginal delivery inflicts a change in the redox status of the mother and the neonate. Hypoxia followed by reperfusion during powerful labour contractions causes increased generation of free radicals affecting the maternal oxidative status. The difference that exists between the extra uterine and intra uterine environment in the partial pressures of oxygen can induce free radical formation which affects the antioxidant mechanism of the neonate during vaginal delivery. The present study was aimed at quantifying the changes with respect to oxidative stress that occurs in uncomplicated laborin both the mother and newborn. Method: 20 singlet on term pregnant women in labour without any complications, delivered by spontaneous vaginal delivery were included in our study. Estimation of plasma MDA (Malondialdehyde) as a marker of lipid peroxidation and antioxidants like SOD (Superoxide dismutase), Total reduced Glutathione (GSH), and Glutathione Peroxidase (GPX) in hemolysate were performed using spectrophotometric method from cord blood and women in labour respectively. Result: The results showed significantly elevated plasma MDA in cord blood compared to maternal plasma MDA, before (P<0.001) and after delivery (P<0.001). Statistically significant higher GSH levels in the cord blood was observed compared to maternal GSH levels both before (P <0.05) and after delivery (P< 0.05). Maternal GPX level was significantly elevated when compared to cord (P< 0.05). However, SOD levels did not show any significant change. Conclusion: Vaginal delivery predisposes the neonate to increased oxidative stress when compared to maternal system which is reflected as an alteration in their antioxidant levels.

Keywords: Antioxidants, Lipid peroxidation, Oxidative stress, Labour
A prospective randomized trial to compare the effectiveness of honey
vs. silver sulfadiazine dressing in burn wound management

A prospective randomized trial to compare the effectiveness of honey vs. silver sulfadiazine dressing in burn wound management

Authors: K N Choudhary, S K. Mohanty, P Soni
( 0 downloads)
Abstract

Introduction: In tribal part of central India burn injuries is a major cause of morbidity and mortality. This trail carried out at Chhattisgarh institute of medical sciences, Bilaspur intended to evaluate the efficacy and outcome of local application of honey vs. conventional silver sulfadiazine dressing treatment of burn wound. Methods: The study encompasses 200 patient of burn injury of varied aetiology admitted in burn ward whose total body surface area of burn was 15% to less than 50%. The patient receiving local application of honey were in group I (n=100) and those with conventional silver sulfadiazine ointment dressing treatment formed group II (n=100). Honey local application dressing was done on alternate day for 6 weeks of follow up period. The major outcome was, complete healing after 6 weeks period, while wound healing status was assessed at 2 weeks interval. Result: 52 out of 100 subject in honey treated group achieved complete healing as compare to 16 out of 100 subjects in silver sulfadiazine treated group. There was significant decrease in wound surface area, pain score & increase in comfort score in honey treated group in comparison to silver sulfadiazine ointment treated group at 0.00 level of significance. Conclusion: Markedly inexpensive honey as local application is highly effective in achieving complete healing in burn wound and is a very use full alternative for burn wound management

Keywords: Honey local application, Silver Sulfadiazine Ointment & Burn Wound
Readdressing the role of therapeutic drug monitoring for antiepileptic
drugs – A tertiary care hospital experience

Readdressing the role of therapeutic drug monitoring for antiepileptic drugs – A tertiary care hospital experience

Authors: Radhika Soanker, Shobha JC Udutha, Ramesh Kumar Rao
( 0 downloads)
Abstract

Background: Therapeutic drug monitoring is a beneficial tool to supervise patients when they do not respond to a therapeutic dose. Inter individual variability in the concentration of an antiepileptic drug that produces optimal therapeutic response is highly significant. Therefore, this retrospective study was taken up to study the inter relation between antiepileptic drug dosages, serum concentration sand clinical condition in the Indian patients. Materials and Methods: This is a retrospective study, in which the data of the samples of adult patients of either gender, analyzed for Phenytoin, Valproate, Carbamazepine and Phenobarbitone were included. The samples were stratified based on dosage prescribed. The endpoints were to estimate the percentage of samples of each stratum having sub therapeutic, therapeutic and supra therapeutic concentrations. Results: Of the 134 samples included, 114 (85%) were analyzed for phenytoin, 9 for valproate, 7 for carbamazepine and 4 for phenobarbitone. Of the 114 samples analyzed for phenytoin, 61(53.5%) samples were having sub therapeutic concentrations, 22 samples (19.3%) had therapeutic concentrations and 31 samples (27.2%) had toxic concentrations. Among the 61 samples having sub therapeutic concentrations, 54.1% were prescribed dose of 300-350mg/day, 16.4% were on 350-400 mg/day and 1.6% were taking above 400mg/day. Of the total cases referred, 41.8 % had H/O of seizures and 30.6% presented with toxic symptoms. Conclusion: This study demonstrated unpredictable inter individual variability in clinical response based on reference ranges. However, the relevance of individual reference concentrations for predicting outcomes can only be confirmed through adequately controlled randomized studies

Keywords: Therapeutic drug monitoring, individual reference concentrations, Antiepileptic drugs.
VHL protein expression in renal cell carcinoma

VHL protein expression in renal cell carcinoma

Authors: Rita Yadav, Mala Sagar, Malti Kumari, Atin Singha, Suresh Babu,, Ashutosh Kumar
( 0 downloads)
Abstract

Introduction: Various studies have been performed to detect VHL gene mutation in renal cell carcinoma (RCCs) but there is paucity of literature analyzing VHL expression at the protein level. Present study was carried out to analyze VHL protein (pVHL) expression in the tissue of RCCs and its correlation with tumor grade & stage. Material and methods: Immunohistochemical detection of pVHL was done by using a mouse monoclonal antibody raised against amino acids 54-213 of VHL of human. Statistical analysis was done by using chi-square test and Kruskall Wallis H Test. Results: 32 patients of renal cell carcinoma were included in the study. pVHL expression was positive in 84.40% cases . Among all pVHL positive cases, combined cytoplasmic and nuclear expression of pVHL was most common (59.0%). Exclusive nuclear expression alone was rare and was noted in only one case. Chromophobe RCC (1 case) was negative for p VHL. Exclusive cytoplasmic pVHL expression was more frequently noticed in low grade tumors. Conclusion: VHL protein expression and its cytoplasmic and nuclear distribution is of potential relevance for the diagnosis and biological behavior of RCCs. Combined nuclear and cytoplasmic expression of VHL protein is more frequently seen in low grade and early stage of renal cell carcinomas.

Keywords: VHL gene, VHL Protein, Renal cell carcinoma, immunohistochemistry, clinical relevance.
Role of vitamin B supplementation with Fluoxetine in treatment of
depression: A randomized controlled clinical trial

Role of vitamin B supplementation with Fluoxetine in treatment of depression: A randomized controlled clinical trial

Authors: Sachin Kuchya,, Sanjay Gedam, Lalit Lakhwani
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Abstract

Objective: To explore the change in antidepressant efficacy of Fluoxetine with vitamin B supplementation. Methods : The present study is a Single Centre, Open Label, Active Controlled, Parallel, and Single Period 8- Week study of 53 patients. Patients are divided in to two groups Fluoxetine alone group which contain 26 patients and Fluoxetine plus vitamin B group which contain 27 patients, after recruitment they were followed up and assessed for CG Impression & on HDRS score and for objective assessment. The primary outcome was observed by improvement in HDRS scores. Response to treatment, and Reduction in HDRS score is analyzed by Un- paired t test. Results: In study subjects clinically significant improvement was observed in fluoxetine plus neurotropic vitamins group as compared to fluoxetine alone group. However statistical analysis shows different results, unpaired t test when applied for the comparison of outcome in the two related samples, the t observed = 4.000. The t observed value falls out of the acceptance region t reference = 1.717. Therefore the null hypothesis stands valid. Conclusion: Fluoxetine plus vitamin B supplementation is not superior to Fluoxetine alone, for moderate to severe cases of mental depression without psychotic symptoms

Keywords: Vitamin B, Fluoxetine, HDRS - Hamilton depression rating score

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