Chronic Diseases Journal

Chronic Diseases Journal

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  • Publisher: Chronic Diseases Journal
  • Country of publisher: iran, islamic republic of
  • Date added to EuroPub: 2019/Nov/09

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  • Language of fulltext: english

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  • Waiver policy for charges? No

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  • Year open access content began: 2013
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

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This journal has '115' articles

Effectiveness of topical Clinda Soap in the treatment of acne vulgaris

Effectiveness of topical Clinda Soap in the treatment of acne vulgaris

Authors: Farrokh Rad, Mansoor Mirbagheri, Mohammad Hossein Pakdaman, Roxana Yaghmaee, Fardin Gharibi
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Abstract

BACKGROUND: A variety of drugs can be used for the treatment of acne vulgaris. Every medicine acts against one or some of the mechanisms of the pathogenesis of acne vulgaris. This study was conducted to assess the therapeutic effect of Clinda Soap in the treatment of acne vulgaris. METHODS: This randomized, double-blind, clinical trial included 82 patients (age: 15-35 years) with mild to moderate acne vulgaris. The study protocol was approved by the ethics committee of Kurdistan University of Medical Sciences (Sanandaj, Iran). The patients were randomized into two groups to receive the standard treatment for acne vulgaris with either Clinda Soap (containing clindamycin hydrochloride 1%, manufactured by Shadakish Company, Iran) or a placebo soap. Both the intervention and control groups were asked to apply soaps twice daily for three months. Monthly examinations were performed by a dermatologist to ensure proper use of the soaps and to assess the rate of recovery and possible complications. Data was analyzed using repeated measures analysis of variance in SPSS. RESULTS: The mean age of patients was 21.1 ± 4.7 years in the intervention group and 21.5 ± 4.8 years in the control group. The mean duration of the disease was 3.0 ± 1.5 and 3.1 ± 1.8 months in the intervention and control groups, respectively. The mean number of comedones in the two groups had no significant difference at any monthly visit. In contrast, at all visits, significantly fewer papules and pustules were observed in the intervention group than in the control. Significant intra-group and inter-group differences in the number of inflammatory lesions (papules and pustules) were also seen. CONCLUSION: In general, it can be concluded that Clinda Soap is effective in the treatment of acne vulgaris. The recovery rate of papules and pustules was higher than that of comedones. Easy application of this soap together with its low cost and few adverse effects will increase patients' compliance.

Keywords: Acne Vulgaris, Clinda Soap, Treatment
Diagnostic value of high sensitivity C-reactive protein in differentiating unstable angina from myocardial infarction

Diagnostic value of high sensitivity C-reactive protein in differentiating unstable angina from myocardial infarction

Authors: Reza Madadi, Katayoon Haddadian, Ebrahim Ghaderi, Kajal Karimi
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Abstract

BACKGROUND: Differentiating between unstable angina and myocardial infarction (MI) is clinically important as they require different treatments. High sensitivity C-reactive protein (hs-CRP) has recently been recognized as prognostic factor in acute coronary syndrome. Since this biomarker may indicate the prognosis of heart disease, identifying its diagnostic value will be clinically important. This study investigated the diagnostic value of the level of hs-CRP in differentiating MI from unstable angina. METHODS: Blood samples were obtained from all patients with suspected MI or unstable angina at the time of referral. The patients were put in one of the two groups based on final diagnosis. The exclusion criteria were infectious diseases, immune system diseases, history of a recent surgery or trauma, kidney failure, liver failure, cancers, and use of anti-inflammatory drugs. Data was entered in SPSS and analyzed by independent t, Mann- Whitney U and chi-square or Fisher’s exact tests. ROC curve was used to determine hs-CRP cut-off point. The sensitivity and specificity were calculated at the cut-off point. RESULTS: Overall, 60 patients (30 patients with MI and 30 patients with unstable angina) were studied. Hs-CRP level was 3.68 ± 0.86 mg/l in patients with MI and 2.35 ± 1.30 mg/l in patients with unstable angina (P < 0.001). The best cut-off point for differentiating unstable angina from MI was hs-CRP levels equal to or greater than 3.27 mg/l. At this cutoff point, the sensitivity and specificity were both 77%. CONCLUSION: Patients with MI had higher levels of hs-CRP than subjects with unstable angina. Hs-CRP levels equal to or higher than 3.27 mg/l are more likely to be associated with MI. It is recommended to test this biomarker in all patients with acute coronary syndrome.

Keywords: Myocardial Infarction, Acute Coronary Syndrome, Unstable Angina, Diagnosis
Impacts of osteoporosis on quality of life in elderly women

Impacts of osteoporosis on quality of life in elderly women

Authors: Abolfazl Mohammadbeigi, Jafar Hassanzadeh, Narges Mohammadsalehi, Bagher Nasimi, Gholamhossein Ranjbar-Omrani
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Abstract

BACKGROUND: Osteoporosis, the most common pathological cause of skeletal weakening and the most common metabolic bone disease, is caused by loss of bone mass density (BMD). Fractures due to osteoporosis will worsen life, increase pain, and decrease quality of life. The present study aimed to determine the impact of osteoporosis on quality of life among elderly women. METHODS: In a cross-sectional study, 275 postmenopausal women (age: 50-70 years) who were referred to the Namazi Hospital (Shiraz, Iran) were included. BMD was measured according to the World Health Organization (WHO) standards. Women with BMD < -2.5 standard deviation (SD) of the average value in young adults were defined as osteoporosis cases. Women with BMD > 1 SD of the average value were defined as normal cases. Quality of life was measured by Qualeffo-41 Questionnaire and reported on a scale of 100. Data was analyzed in SPSS and P values less than 0.05 were considered significant. RESULTS: The mean quality of life score was 25.5 ± 11.7. According to the definition by the WHO, 70.2% of the participants were affected with osteoporosis. Only 22.3% of osteoporotic women and 30.5% of normal subjects had good quality of life. A significant statistical difference was observed between osteoporotic and normal postmenopausal women in social activities. Overweight and low education were predictors of poor quality of life in multivariate analysis. CONCLUSION: The imposed financial burden and complications of osteoporosis can affect the patients’ quality of life. Health education regarding nutritional behaviors and social activities at adolescence are helpful interventions for decreasing the prevalence of the disease. Since osteoporosis has a gradual, outward, and asymptomatic trend, more attention needs to be paid to preventive and screening programs.

Keywords: Quality of Life, Osteoporosis, Menopause, Female, Qualeffo-41 Questionnaire
Comparative analysis of morphometric parameters of intercondylar notch in patients with and without anterior cruciate ligament tears

Comparative analysis of morphometric parameters of intercondylar notch in patients with and without anterior cruciate ligament tears

Authors: Nazanin Farshchian, Satar Sohrabi, Mansour Rezaei
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Abstract

BACKGROUND: Anterior cruciate ligament (ACL) injury is the most common type of ligament injury whose prevalence is higher in athletes. There are different external risk factors for this injury. However, it is important to find its physiological risk factors, as well. This study assessed the relationship between morphometric parameters of intercondylar notch and ACL tears in patients suffering from knee complications. METHODS: Patients with or without ACL tears who had undergone knee magnetic resonance imaging for any reason were recruited based on inclusion criteria. Intercondylar notch width, femoral bicondylar width, and intercondylar notch index were calculated in both groups. Then, significant variables from univariate analysis were entered in multiple regression analysis with intercondylar notch width, femoral bicondylar width, and intercondylar notch index being assumed as dependent variables. RESULTS: Overall, 199 participants, including 81 patients with ACL tear and 118 without ACL tear, were evaluated. Multiple regression analysis revealed intercondylar notch width and intercondylar notch index to be less common among women and subjects with ACL tears (P < 0.001). CONCLUSION: Based on the results of this study, there are relationships between ACL tears and being female and intercondylar notch width. Therefore, intercondylar notch index can be used for screening athletes and people at risk of ACL tears.

Keywords: Anterior Cruciate Ligament Tear, Intercondylar Notch, Femoral Bicondylar Width, Intercondylar Notch Index
Risk factors of chronic obstructive pulmonary disease in men and women in Sanandaj, Iran

Risk factors of chronic obstructive pulmonary disease in men and women in Sanandaj, Iran

Authors: Naseh Sigari, Fatemah Alhani, Jamal Seidi, Ghader Salehnejad, Alireza Gharib, Daem Roshani
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Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the world. While smoking has been identified as the main cause of COPD in many studies, other causes may include environmental pollution and genetic vulnerability in both genders. Considering lifestyle of rural women, and the old structure of Sanandaj (Kurdistan Province, Iran) which is different with other parts of the country, this study compared the risk factors for COPD in men and women. METHODS: In a descriptive, analytic study 400 subjects of both genders (200 female and 200 male) were evaluated. The files of patients with COPD admitted to Besat Hospital (Sanandaj, Iran) during 2006-11 were randomly selected using a systematic sampling method. The sampling continued until a total of 200 patient files were collected in each group. Eventually, data was analyzed with SPSS. RESULTS: Smoking was the major risk factor (56.5%) for COPD in both men and women (n = 226). While only 32.5% of women (n = 65) had a history of smoking, the rate was as high as 80.5% in men (n = 161). Most women (60.5%) were more exposed to fossil fuel smoke than men. Fisher’s exact test results showed a significant difference in the risk factors (including Smoking and tobacco use, Exposure to fossil fuel smoke and air pollution) and the type of jobs between the two genders. CONCLUSION: Based on the results of our study, it is better to obtain an accurate history of exposure to smoke of wood or biomass and a history of residing in rural areas as the main risk factors for developing COPD in patients who have no history of high-risk occupations or other risk factors of the disease (e.g. smoking).

Keywords: Chronic Obstructive Pulmonary Disease, Epidemiological Study, Risk Factors
A survey of factors related to urine iodine levels in elementary school children, Kurdistan, Iran

A survey of factors related to urine iodine levels in elementary school children, Kurdistan, Iran

Authors: Mehdi Zokai, Amin Amini, Farzam Bidarpoor, Mohammad Tamimi
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Abstract

BACKGROUND: Iodine deficiency disorders (IDD) control program has two important factors: annual monitoring of urine iodine levels and controlling iodized salt consumed in the community. Preserving the iodine indexes in different level is important now too. This survey determined factors affecting median levels of urine iodine levels in students of Kurdistan Province (Iran). METHODS: This cross-sectional study selected 255 8-10-year-old students using cluster random sampling. Data was obtained by a questionnaire and urine analysis. The collected data was analyzed by Mann-Whitney and Kruskal-Wallis tests, Spearman correlation, and multiple regression. All analyses were performed using SPSS. RESULTS: The median urine iodine level of the studied school children was 9.7 μg/dl. There was no significant relation between urine iodine level and sex, place of residence (rural/urban areas), and household iodized salt intake (r = 0.188, P = 0.003). Overall, 119 families (46.7%) did not appropriately protect their iodized salt. The amount of iodine in salt and the condition in which salt is kept had relationships with children’s urine iodine levels. CONCLUSION: Low median level of urine iodine in students, low household iodized salt, and high use of salt with lesser iodine than the standard value showed that the IDD program in Kurdistan Province has not been successful. Therefore, there is a risk for increased prevalence of Goiter in the region. We recommend interventional programs to improve the current status in the province.

Keywords: Goiter, Urine Iodine, Iran
Effectiveness of an educational intervention on pain duration and severity of herniated disc

Effectiveness of an educational intervention on pain duration and severity of herniated disc

Authors: Kheiriollah Moradi, Mokhtar Yaghoubi, Daem Roshani, Alireza Gharib
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Abstract

BACKGROUND: One of the causes of low back pain is herniated disc that puts pressure on the nerve roots and cause pain radiating down the legs. Specific body movements tend to aggravate pain. Among treatment approaches, patient education could be considered as an effective way of pain management. We did not find any study showing the effects of educational intervention on pain management in searched medical literature. This study aimed to investigate effects of educational intervention on the level of pain due to herniated disc. METHODS: In this study, 83 patients with lumbar disc pain were selected and pain intensity and duration were recorded based on a scale from one to ten. The average pain intensity and duration before and after intervention were recorded. Then the data were analyzed using SPSS software. RESULTS: Frequency of L4-L5 herniated disc was 39.7%, L5-S1 was 36.1% and L4-S1 was 24.1%. Mean intensity of pain before intervention was 8.33. After intervention, duration of pain decreased from 8.34 ± 0.73 to 6.76 ± 5.54 (P < 0.001) and mean duration of pain before and after intervention were 65.6 ± 5.21 and 53.5 ± 5.83 minutes, respectively (P < 0.001). CONCLUSION: Educational intervention for patient with lumbar herniated disc could be used as a practical complementary method beside other therapeutic approaches in the treatment of low back pain.

Keywords: Educational Intervention, Pain, Herniated Disk, Low Back Pain
Treatment of Behcet’s disease

Treatment of Behcet’s disease

Authors: Fereydoun Davatchi, Nasrin Moghimi, Mohammad Mousavi, Alimohammad Fatemi
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Abstract

Behcet’s disease is a systemic disease classified among vasculitides. Major manifestations are mucous membrane lesions (oral aphthosis and genital aphthosis), skin manifestations (pseudofolliculitis, erythema nodosum), ocular manifestations (uveitis, retinal vasculitis), joint manifestations, vascular lesions (small to large vessel thrombosis, aneurysm), gastrointestinal manifestations, orchiepididymitis, and some rare manifestations like cardiac, pulmonary, and renal impairment. Diagnosis is mainly clinical. The International Diagnosis Criteria for Behcet’s Disease may be of help. The gold standard of treatment for mucocutaneous lesions is colchicine. In refractory cases, levamisole, thalidomide, and dapsone may be of help. For major organ involvement like the eyes and the brain, immunosuppressive drugs and prednisolone are the gold standard. In refractory cases, biological agents are the last resort. For gastrointestinal manifestations, sulfasalazine and prednisolone are the first-line treatment. For vascular involvement, the first line treatment was anticoagulation, but recently it was shown that immunosuppressive drugs and prednisolone were confirmed to be the best. In all refractory cases and for all different organs, the last resort is biological agents.

Keywords: Behcet’s Disease, Treatment, Manifestation, Diagnosis
Effect of designed self-care educational program on anxiety, stress, and depression in patients with benign prostatic hyperplasia undergoing prostate surgery

Effect of designed self-care educational program on anxiety, stress, and depression in patients with benign prostatic hyperplasia undergoing prostate surgery

Authors: Mehdi Beyramijam, Monireh Anoosheh, Eesa Mohammadi
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Abstract

BACKGROUND: Stress, anxiety, and depression are common psychological problems in prostatic conditions. The aim of this study was to investigate the effects of designed self-care educational program on anxiety, stress, and depression in patients with benign prostatic hyperplasia undergoing prostate surgery. METHODS: This was a quasi-experimental study including 33 participants in the intervention group and 34 participants in the control group. During the study demographic data and the rate of stress, anxiety, and depression were measured. In the intervention group, self-care educational program was presented in two sessions and was followed up one month after surgery. Stress, anxiety, and depression were measured before surgery, and during and one month after discharge using depression anxiety stress scales (DASS-21), which is a standard questionnaire. Later data were analyzed using SPSS software. RESULTS: Participants in the study were between 45-80 years of age. Student’s independent t-test before the intervention revealed no significant difference in mean score of stress (P = 0.684), anxiety (P = 0.937), and depression (P = 0.727) between the two groups. Mean score of stress and anxiety significantly reduced in the intervention group on discharge (stress: P = 0.031, anxiety: P = 0.043), and a month after the operation (stress: P ≤ 0.001, anxiety: P = 0.016). However, mean score of depression revealed no significant difference on discharge (P = 0.514), and a month after operation (P = 0.221). CONCLUSION: The results showed that designed self-care educational program was effective in stress and anxiety reduction in patients under prostate surgery.

Keywords: Self-Care, Stress, Anxiety, Depression, Benign Prostatic Hyperplasia
Quality of life among Iranian postmenopausal women participating in a health educational program

Quality of life among Iranian postmenopausal women participating in a health educational program

Authors: Gholrokh Moridi, Roonak Shahoei, Shahnaz Khaldi, Fariba Sayedolshohadaei
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Abstract

BACKGROUND: Quality of life (QOL) in postmenopausal period has taken much attention especially in recent years, since almost one third of woman are living in postmenopausal age. The aim of this study was to determine the effect of health educational program among Iranian postmenopausal women. METHODS: This quasi-experimental study was conducted in Sanandaj (Kurdistan, Iran). Forty menopausal women were recruited for the study. Data were collected using the Persian version of menopause-specific quality of life questionnaire (MENQOL) at the University of Toronto, Canada. After an initial evaluation and estimation of educational needs, educational intervention was performed weekly, for three consecutive weeks; each section lasted 45-60 minutes. The inclusive criteria were age of 45 years or older, married, residing in Sanandaj, having normal pressure and not using any types of alternative hormone therapy 6 months prior to the study. RESULTS: Mean age was 45.5 ± 2.5 years. Results showed that the mean score of QOL scale positively was affected by the health educational program. CONCLUSION: This study showed that an appropriate training to menopausal women can improve their QOL and promote their health.

Keywords: Education, Menopause Women, Quality of life
Comparison the efficacy of Hypericum perforatum and vitex agnus-castus in hot flushes: A double-blinded randomized controlled trial

Comparison the efficacy of Hypericum perforatum and vitex agnus-castus in hot flushes: A double-blinded randomized controlled trial

Authors: Masumeh Ghazanfarpour, Ebrahim Ghaderi, Kazhal Haddadian
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Abstract

BACKGROUND: Treating hot flushes in middle-aged women is an important health issue. Recently, Hypericum perforatum and vitex agnus-castus were investigated to decrease hot flushes. This study was conducted to compare the efficacy of Hypericum perforatum and vitex agnus-castus in hot flushes among menopausal women. METHODS: This was a randomized, double-blinded, controlled trial. The Hypericum perforatum group received 330 μg Hypericum perforatum and second group received vitex agnus-castus in the same tablet forms. Data were analyzed using repeated measurement for comparing Greene Climacteric Scale. RESULTS: Trend of Greene Climacteric Scale and hot flushness attack were decreased in both groups and it presented a decreasing trend within two months; however, no statistically significant difference was observed between the two groups. CONCLUSION: It seems that Hypericum perforatum and vitex agnus-castus could be similarly effective in decreasing hot flushes. These two medicines did not have any special severe side effects.

Keywords: Hypericum, Menopause, Plants, Randomized Controlled Trial, Vitex Agnus-Castus, Herbal Drug
Comparing the therapeutic effects of three herbal medicine (cinnamon, fenugreek, and coriander) on hemoglobin A1C and blood lipids in type II diabetic patients

Comparing the therapeutic effects of three herbal medicine (cinnamon, fenugreek, and coriander) on hemoglobin A1C and blood lipids in type II diabetic patients

Authors: Mohsen Zahmatkesh, Mohammad Khodashenas-Roudsari
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Abstract

BACKGROUND: Cinnamon, fenugreek and coriander are among those herbs that are probably effective in lowering glucose; however, different results have been found in observed studies, and the effectiveness of these herbs is still controversial. This study was designed to compare the effects of three herbs of cinnamon, fenugreek and coriander on hemoglobin A1C (HbA1C) and blood lipids in type II diabetic patients. METHODS: This was a double-blind randomized controlled trial study and 150 non-insulin dependent diabetic patients were recruited in the study. Five similar concolor 500mg capsules containing cinnamon, fenugreek, coriander, -a mixture of three herbs-, and placebo were prescribed two capsules every 12 hours. Variables of HbA1C, fasting blood glucose, cholesterol and triglyceride were tested after 6 weeks. Data were analyzed by chisquare, Fisher’s exact test, Mann-Whitney test and one way analysis of variance (one-way ANOVA). RESULTS: There was no statistical significant difference between the intervention and placebo groups regarding basic characteristics. Man age of patients was 53.76 ± 8.74 years and the disease duration was 8.00 ± 5.66 years. Mean fasting blood sugar (FBS) and HbA1C was 189.4 ± 51.05 mg/dl and 9.2 ± 1.42 percent, respectively. CONCLUSION: In type II diabetic patients, herbal medicines of cinnamon, fenugreek, and coriander and their mixture with a daily dosage of 2 g did not have any stronger effect than the placebo on lowering blood glucose, HbA1C, and blood lipids; it might be the result of several factors including prescribing little amounts of medicine, short period of intervention, and ineffectiveness of the mentioned herbs.

Keywords: Diabetes, Cinnamon, Fenugreek, Coriander, Hemoglobin A1C, Blood Lipids
The barriers of failure to meet the codes of professional ethics from viewpoints of nursing staff in Tehran University of Medical Sciences, Iran in 2011

The barriers of failure to meet the codes of professional ethics from viewpoints of nursing staff in Tehran University of Medical Sciences, Iran in 2011

Authors: Ali Dehghani, Sima Mohammadkhan-Kermanshahi, Morteza Gholami
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Abstract

BACKGROUND: Compliance with nursing ethics leads to improvement in nursing care. Therefore, this study carried out to determine the barriers of failure to meet the codes of nursing ethics from the viewpoint of nursing staff. METHODS: This was a descriptive cross-sectional study conducted on 138 nursing staff in Tehran University of Medical Sciences (Tehran, Iran) by random sampling method using a demographic questionnaire. RESULTS: 50% of the barriers of failure in meeting with codes of professional ethics were contributed to management, 25.4% to environmental aspect, and 24.6% to individual care. Results indicated that there was no statistically significant difference between the demographic variables and the barriers of failure to meet the codes of professional ethics. CONCLUSION: Given the management, as the most important barrier, it is suggested to enhance the awareness and knowledge of nursing ethics in nurses.

Keywords: Barriers, Nursing Staffs, Codes of Professional Ethics
Undetected leprosy in an endemic area: A case report

Undetected leprosy in an endemic area: A case report

Authors: Shahla Afrasiabian, Alireza Gharib, Katayoun Hajibagheri
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Abstract

Leprosy is an infectious disease causing irreversible disability if unnoticed. A 69-year-old man with undetected leprosy from 30 years ago referred to us with claw hand and Madrosis (Milphosis). The patient complained of non-healing and painless ulcers on the extremities as well as numbness in the right leg. He told the medical team that he could not feel his feet in his shoes. The patient had blurred vision and lacrimation two weeks before admission. He had a history of recurrent foot ulcers from 25 years ago although he referred to medical staff about 5 years ago with infected wound on the hands and multiple scars of pervious ulcers. The disabilities were mainly in consequence of late visit to healthcare centers, misdiagnosis, difficult access to medical centers and patient's unawareness. The case showed the significance of medical education and public awareness for signs and symptoms of leprosy to be recognized and treated on time. In conclusion detecting leprosy should not be delayed just because of a decrease in the number of cases especially in an endemic area like Kurdistan, Iran.

Keywords: Leprosy, Chronic Disease, Disability, Mycobacterium Leprae
Hereditary spherocytosis in an 18-month-old boy with pancytopenia: A case report 	PDF

Hereditary spherocytosis in an 18-month-old boy with pancytopenia: A case report PDF

Authors: Borhan Moradveisi, Soran Ghafouri, Abdollah Sedaghat
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Abstract

Hereditary spherocytosis (HS) is a familial hemolytic disorder with marked heterogeneity of clinical features, ranging from an asymptomatic condition to a fulminant hemolytic anemia. Although a positive family history of spherocytosis increases the risk for this disorder, it may be sporadic in some cases. In severe cases the disorder may be detected in early childhood, but in mild cases it may go unnoticed until later in adulthood. The case was an 18-month-old boy from Sanandaj, Iran with 3 days decreased activity movement, poor feeding, pallor and urine discoloration since 3 days ego following an episode of fever. He was a case of anemia who was managed conservatively on nutritional supplements. Blood film showed 80% spherocytes, reticulocyte was 0.5%, increased osmotic fragility test and a negative direct Coombs.

Keywords: Hereditary Spherocytosis, Familial Hemolytic Disorder, Hemolytic Disorder, Anemia, Spherocytes, Reticulocyte, Osmotic Fragility Test

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