Scripta Medica (Banja Luka)

Scripta Medica (Banja Luka)

Basic info

  • Publisher: Association of Medical Doctors of the Republic of Srpska
  • Country of publisher: bosnia and herzegovina
  • Date added to EuroPub: 2019/Nov/23

Subject and more

  • LCC Subject Category: Medicine, Research & Experimental, Dentistry, Oral Surgery & Medicine, Radiology, Nuclear Medicine & Medical Imaging, Pharmacology & Pharmacy, Medicine, General & Internal, Emergency Medicine, Critical Care Medicine, Medicine, General & Internal
  • Publisher's keywords:
  • Language of fulltext: english

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Editorial information

Open access & licensing

  • Type of License:
  • License terms
  • Open Access Statement: No
  • Year open access content began: 1966
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier:
  • Content digitally archived in:
  • Deposit policy registered in:

This journal has '10' articles

Nerve agents – a clear and present danger to mankind

Nerve agents – a clear and present danger to mankind

Authors: Miloš P. Stojiljković
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Abstract

This editorial is written on the occasion of the 25th anniversary of the infamous sarin and VX terrorist attacks in Japan, in order to increase the awareness of the potential terrorist use of nerve agents and to urge the preparedness to cope with its consequences. Nerve agents are extremely toxic organophosphorus acetylcholinesterase inhibitors, divided in three known groups: G-, V- and A-agents. G-agents tabun, sarin and soman were synthesised in Nazi Germany (1938-1944), V-agents including VX by the British in the 1950s and A-agents or Novichok agents between 1971 and 1993 in the Soviet Union. The use or alleged use of tabun and sarin was mentioned in connection with the Iraq-Iran war (1980-1988) and the Syrian conflict in 2013 and 2017. Sarin and VX were used for terrorist purposes by the Japanese religious sect AUM Shinrikyo in 1994 and 1995. The assassination of Kim Jong Nam with VX took place in Kuala Lumpur, Malesia in 2017, while the 2018 Salisbury and Amesbury poisonings in the UK were ascribed to the so-called Novichok agent A234. Milder cases of poisoning with nerve agents is accompanied by predominantly muscarinic symptomatology and more massive intoxications with mainly nicotinic and central symptoms. Treatment consists of use of atropine, oximes and anticonvulsants.

Keywords: nerve agent. tabun. sarin. soman. VX. Novichok. atropine. oxime. anticonvulsant.
The effects of certain gasotransmitters inhibition on homocysteine acutely induced changes on rat cardiac acetylcholinesterase activity

The effects of certain gasotransmitters inhibition on homocysteine acutely induced changes on rat cardiac acetylcholinesterase activity

Authors: Marko Djuric, Slavica Mutavdzin, Dragana Loncar-Stojiljkovic, Sanja Kostic, Mirjana B. Colovic, Danijela Krstic, Vladimir Zivkovic, Dragan M. Djuric
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Abstract

Background/Aim: Hyperhomocysteinaemia is linked to higher level of acetylcholinesterase (AChE) in brain, but there is insufficient information on influence of homocysteine (Hcy) and gasotransmitters on cardiac AChE. Thus, the aim of this study was to evaluate the influence of certain gasotransmitter inhibitors in Hcy-induced changes on rat cardiac AChE activity. Methods: Research was performed on 72 male Wistar albino rats distributed into 6 groups: 1) Control group – saline (1 ml 0.9 % NaCl ip); 2) DL-Hcy (8 mmol/kg ip DL homocysteine (DL-Hcy); 3) L-NAME (10 mg/kg ip N ω -Nitro-L-arginine methyl ester (L-NAME), inhibitor of NO production); 4) DL-PAG (50 mg/kg ip DL-propargylglycine (DL-PAG), inhibitor of H2S production); 5) DL-Hcy+L-NAME (8 mmol/ kg ip DL-Hcy + 10 mg/kg ip L-NAME); and 6) DL-Hcy+DL-PAG (8 mmol/kg ip DL-Hcy + 50 mg/kg ip DL-PAG). All tested substances were administered in a single dose, intraperitoneally, 60 minutes before animals’ sacrifice. AChE activity was measured in the rats’ cardiac tissue homogenate. Results: Administration of Hcy and L-NAME induced significant decrease in AChE activity compared with control condition. Administration of DL-PAG, DL-Hcy+LNAME and DL-Hcy+DL-PAG did not change AChE activity compared with the control group. Conclusion: The effects of acute Hcy administration on the cardiac AChE activity are partially mediated via interaction with tested gasotransmitters.

Keywords: acetylcholinesterase. heart. homocysteine. inhibition.
Dermal regeneration with MilliGraft® kit of nanofat: the micrograft of adipose tissue. A clinical assessment study

Dermal regeneration with MilliGraft® kit of nanofat: the micrograft of adipose tissue. A clinical assessment study

Authors: Fabiano Svolacchia, Lorenzo Svolacchia
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Abstract

The simple filtration by means of the MilliGraft ® Kit of a disaggregated lipoaspirate allows to extract the class of cells defined as progentors with characteristics of adult stem cells present in the nanofat exclusively on the basis of their dimensions. It also allows the elimination of the fibrous branches and cell membranes destroyed by the emulsion phase and obtain a population of cells deprived of the inflammatory component. This method was used in regenerative and aeshetic medicine treatments with excellent and lasting clinical results in the follow-up phase.

Keywords: dermal regeneration. nanofat. mesenchymal stromal progenitor cells. microfiltrate. MilliGraft®.
Multimodal neural block analgesia versus morphine analgesia after elective knee surgery

Multimodal neural block analgesia versus morphine analgesia after elective knee surgery

Authors: Dragana Lončar-Stojiljković
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Abstract

Background: Total knee arthroplasty has become a standard for treatment of endstage knee osteoarthritis. Due to intense and complex knee innervation, there is a need to improve the anaesthetic/analgesic approach to such operations. The aim of this randomised clinical trial was to compare the analgesic efficacy of the classical regimen and two of those based on the nerve blocks. Methods: A total of 60 patients was included and subjected to elective total knee arthroplasty under the general balanced anaesthesia. They were randomised to receive postoperatively (1) only morphine 5-10 mg q6h and paracetamol 1 g q6h (MP), (2) femoral nerve block (FNB) or (3) fascia iliac compartment nerve block (FICNB). Nerve blocks were produced by a single administration of 30-40 ml of bupivacaine 0.5%. Pain intensity, duration of neural block and additional consumption of analgesics were recorded postoperatively. Results: There were no demographic differences among the three groups of patients. Pain intensity was significantly lower in the two nerve block groups than in the MP group. The same two groups also demanded significantly less analgesics postoperatively than the MP group. Cardiovascular control was significantly better in the nerve block groups. There were no significant differences between the FNB and FICNB groups of patients regarding any of the studied parameters. Conclusion: In comparison with the classical MP analgesia, use of FNB or FICNB after the elective total knee arthroplasty results in lower pain scores, lower systolic blood pressure and less consumption of analgesics in the immediate postoperative course.

Keywords: knee arthroplasty. anaesthesia. nerve block. morphine. paracetamol.
Renin-angiotensin and kallikrein-kinin systems in diabetic retinopathy

Renin-angiotensin and kallikrein-kinin systems in diabetic retinopathy

Authors: Rajko Igić
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Abstract

This brief review describes how two complex systems, the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), affect the retina. It emphasises the important physiological actions of components of these systems, the protective effectiveness of angiotensin I converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) in diabetic retinopathy and suggests as well the therapeutic possibilities for treatment of diabetic retinopathy by selective activation of bradykinin receptors (B1 and B2).

Keywords: RAS. KKS. ACE. angiotensin II. kinins. ACE inhibitors.
Quality of life in children with epilepsy

Quality of life in children with epilepsy

Authors: Dimitrije M. Nikolić, Željka Rogač
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Abstract

Children with epilepsy are a particularly sensitive part of population and require continuous monitoring by neuro-paediatricians, so that any behavioural and functional changes that occur during mental maturation from the side effects of the therapy, but also the consequences of the disease itself, could be timely noticed. The aim of this paper is precisely to point out the potential difference in the quality of life of children with epilepsy, through the synthesis of relevant literature, in order to alert the local professional public about the need for mutual cooperation with neuro-paediatricians, psychologists, child psychiatrists, but also social workers and teachers at school.

Keywords: children. epilepsy. quality of life.
Effects of the radial extracorporeal shock wave therapy (rESWT) in patients with calcific tendinopathy of the shoulder

Effects of the radial extracorporeal shock wave therapy (rESWT) in patients with calcific tendinopathy of the shoulder

Authors: Dragana Dragičević-Cvjektović, Tatjana Erceg-Rukavina, Slavko Manojlović
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Abstract

Introduction: Calcific tendinopathy (CT) of the shoulder is frequently a painful condition that is occurring when there are calcium deposits in the tendons of the rotator cuff. There are many options for treatment starting from therapeutic options like medicaments, physical therapy and radial extracorporeal shock wave therapy (rESWT). If conservative treatment fails, surgical treatment is the next option. The purpose of this study was to investigate the outcome effect of rESWT in patients with calcific tendinopathy. Methods: A prospective study from February 2010 to March 2019 monitored 67 patients with CT of the shoulders of the average age of 47.06 ± 15.2 (mean± standard deviation) who were treated with a rESWT. All patients were evaluated clinically with selected radiographic evaluation of the shoulder before therapeutic intervention. The treatment protocol consisted of a sound pressure intensity of 3 bar, a wave frequency of 14/sec, a total of 2,000 waves per session. All patients performed a treatment consisting of three sessions described every seven days. The outcome parameters were VAS scale of pain and shoulder radiography before and after therapy. The Student's t-test was used in the statistical analysis. Results: Clinical and radiographic improvement was recorded in 70% of patients in the treatment of CT of the shoulder 6 weeks after the therapy was performed with a rESWT (p <0.05) in terms of reduced pain and disintegration of calcification. Conclusion: rESWT has showed positive effects in the treatment of patients that have calcific tendinopathy of the shoulder.

Keywords: rESWT. calcific tendinopathy. shoulder.
Surgical treatment of aortic valve fibroelastoma: a case report

Surgical treatment of aortic valve fibroelastoma: a case report

Authors: Stamenko Šušak, Bogdan Okiljević, Strahinja Mrvić, Jovan Rajić, Ranko Zdravković
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Abstract

A 45-year-old man was admitted to Clinic for the first time, with symptoms of chest pain and fatigue. Computerised tomography (CT) diagnostics of the chest showed a soft tissue vegetation of approximately 5x5 mm on the left aortic coronary cusp. A double-vessel coronary disease was also diagnosed. The patient underwent surgery, a complete resection of the tumour was achieved, which was confirmed by postoperative transoesophageal echocardiography (TEE). Because of the risk of valve damage, it was decided to replace the aortic valve. A bypass from left internal mammary artery (LIMA) to left anterior descending (LAD) coronary artery (LAD-LIMA) and right coronary artery (RCA) was also performed. The patient was discharged on the 14th postoperative day with satisfactory results.

Keywords: fibroelastoma. aortic valve. tumour. cardiac surgery.
New dawn fades: from imaging to quantitative imaging biomarkers and beyond

New dawn fades: from imaging to quantitative imaging biomarkers and beyond

Authors: Miloš A. Lučić
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Abstract

In the modern ages of rapid technological and computational advances, development of numerous novel diagnostic imaging techniques have enabled not only visual detection of disease processes, but also provided the tools to achieve quantified functional, structural, dynamic, metabolic, and molecular information. A pathway toward the quantitative imaging by use of quantitative imaging biomarkers analysis has been widely opened, enabling further development of radiomics, radiogenomics, and radioproteinomics analysis in addition, and initiating the dawn of theranostics, eventually bringing the wishful personalized medicine concept closer to reality.

Keywords: Radiology. Diagnostic Imaging. Quantitative Imaging. Quantitative imaging biomarkers. Radiomics. Personalised medicine.
Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix

Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix

Authors: Drage Dabeski, Ana Dabeski, Vesna Antovski, Milka Trajanova, Irena Todorovska, Aneta Sima
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Abstract

Background: Human papillomavirus infections are one of the most common sexually transmitted infections with viral aetiology. The aim of the study was to confirm the existence of an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix. Methods: Cohort study, conducted in the period from January 2017 to June 2018 of 768 sexually active women, age groups of 20 to 59 years, divided into two groups: examined and control, who came to their annual gynaecological exam at University Clinic for Gynaecology and Obstetrics in Skopje. In all patients was done human papillomavirus-deoxyribonucleic testing. Human papillomavirus detection and typing was done using a polymerase chain reaction and reverse hybridisation. Results: Data analysis showed an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix (p=0.00001). Human papillomavirus infection was detected in 22.91% of all patients, in 75.00% of patients with abnormal cervical cytology and in 12.50% of patients with normal cervical cytology. A single human papillomavirus infection was detected in 13.67% of all patients (in 59.66% of human papillomavirus positive patients). Mixed human papillomavirus infection was detected in 9.24% of all patients (in 40.34% of human papillomavirus positive patients). Human papillomavirus type 16 was the most common genotype with 40.91%. Conclusion: This study confirmed that there is an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix and the young population under the age of 30 years is the most affected.

Keywords: human papillomavirus. squamous cell abnormalities. uterine cervix.

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